TY - JOUR
T1 - Future perspective for the application of predictive biomarker testing in advanced stage non-small cell lung cancer
AU - de Jager, Vincent D
AU - Timens, Wim
AU - Bayle, Arnaud
AU - Botling, Johan
AU - Brcic, Luka
AU - Büttner, Reinhard
AU - Fernandes, Maria Gabriela O
AU - Havel, Libor
AU - Hochmair, Maximilian
AU - Hofman, Paul
AU - Janssens, Annelies
AU - van Kempen, Léon
AU - Kern, Izidor
AU - Machado, José Carlos
AU - Mohorčič, Katja
AU - Popat, Sanjay
AU - Ryška, Aleš
AU - Wolf, Jürgen
AU - Schuuring, Ed
AU - van der Wekken, Anthonie J
N1 - © 2024 The Authors.
PY - 2024/3
Y1 - 2024/3
N2 - For patients with advanced stage non-small cell lung cancer (NSCLC), treatment strategies have changed significantly due to the introduction of targeted therapies and immunotherapy. In the last few years, we have seen an explosive growth of newly introduced targeted therapies in oncology and this development is expected to continue in the future. Besides primary targetable aberrations, emerging diagnostic biomarkers also include relevant co-occurring mutations and resistance mechanisms involved in disease progression, that have impact on optimal treatment management. To accommodate testing of pending biomarkers, it is necessary to establish routine large-panel next-generation sequencing (NGS) for all patients with advanced stage NSCLC. For cost-effectiveness and accessibility, it is recommended to implement predictive molecular testing using large-panel NGS in a dedicated, centralized expert laboratory within a regional oncology network. The central molecular testing center should host a regional Molecular Tumor Board and function as a hub for interpretation of rare and complex testing results and clinical decision-making.
AB - For patients with advanced stage non-small cell lung cancer (NSCLC), treatment strategies have changed significantly due to the introduction of targeted therapies and immunotherapy. In the last few years, we have seen an explosive growth of newly introduced targeted therapies in oncology and this development is expected to continue in the future. Besides primary targetable aberrations, emerging diagnostic biomarkers also include relevant co-occurring mutations and resistance mechanisms involved in disease progression, that have impact on optimal treatment management. To accommodate testing of pending biomarkers, it is necessary to establish routine large-panel next-generation sequencing (NGS) for all patients with advanced stage NSCLC. For cost-effectiveness and accessibility, it is recommended to implement predictive molecular testing using large-panel NGS in a dedicated, centralized expert laboratory within a regional oncology network. The central molecular testing center should host a regional Molecular Tumor Board and function as a hub for interpretation of rare and complex testing results and clinical decision-making.
U2 - 10.1016/j.lanepe.2024.100839
DO - 10.1016/j.lanepe.2024.100839
M3 - Review article
C2 - 38476751
SN - 2666-7762
VL - 38
JO - The Lancet Regional Health - Europe
JF - The Lancet Regional Health - Europe
M1 - 100839
ER -