G-quadruplex structures within the 3′ UTR of LINE-1 elements stimulate retrotransposition

Aleksandr B. Sahakyan, Pierre Murat, Clemens Mayer, Shankar Balasubramanian*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

52 Citations (Scopus)

Abstract

Long interspersed nuclear elements (LINEs) are ubiquitous transposable elements in higher eukaryotes that have a significant role in shaping genomes, owing to their abundance. Here we report that guanine-rich sequences in the 3′ untranslated regions (UTRs) of hominoid-specific LINE-1 elements are coupled with retrotransposon speciation and contribute to retrotransposition through the formation of G-quadruplex (G4) structures. We demonstrate that stabilization of the G4 motif of a human-specific LINE-1 element by small-molecule ligands stimulates retrotransposition.

Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalNature Structural and Molecular Biology
Volume24
Issue number3
DOIs
Publication statusPublished - 1-Mar-2017
Externally publishedYes

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