G-quadruplex structures within the 3′ UTR of LINE-1 elements stimulate retrotransposition

Aleksandr B. Sahakyan; Pierre Murat; Clemens Mayer; Shankar Balasubramanian

doi:10.1038/nsmb.3367

G-quadruplex structures within the 3′ UTR of LINE-1 elements stimulate retrotransposition

Aleksandr B. Sahakyan
, Pierre Murat
, Clemens Mayer
, Shankar Balasubramanian^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

67 Citations (Scopus)

Abstract

Long interspersed nuclear elements (LINEs) are ubiquitous transposable elements in higher eukaryotes that have a significant role in shaping genomes, owing to their abundance. Here we report that guanine-rich sequences in the 3′ untranslated regions (UTRs) of hominoid-specific LINE-1 elements are coupled with retrotransposon speciation and contribute to retrotransposition through the formation of G-quadruplex (G4) structures. We demonstrate that stabilization of the G4 motif of a human-specific LINE-1 element by small-molecule ligands stimulates retrotransposition.

Original language	English
Pages (from-to)	243-247
Number of pages	5
Journal	Nature Structural and Molecular Biology
Volume	24
Issue number	3
DOIs	https://doi.org/10.1038/nsmb.3367
Publication status	Published - 1-Mar-2017
Externally published	Yes

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title = "G-quadruplex structures within the 3′ UTR of LINE-1 elements stimulate retrotransposition",

abstract = "Long interspersed nuclear elements (LINEs) are ubiquitous transposable elements in higher eukaryotes that have a significant role in shaping genomes, owing to their abundance. Here we report that guanine-rich sequences in the 3′ untranslated regions (UTRs) of hominoid-specific LINE-1 elements are coupled with retrotransposon speciation and contribute to retrotransposition through the formation of G-quadruplex (G4) structures. We demonstrate that stabilization of the G4 motif of a human-specific LINE-1 element by small-molecule ligands stimulates retrotransposition.",

author = "Sahakyan, \{Aleksandr B.\} and Pierre Murat and Clemens Mayer and Shankar Balasubramanian",

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AU - Sahakyan, Aleksandr B.

AU - Murat, Pierre

AU - Mayer, Clemens

AU - Balasubramanian, Shankar

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Long interspersed nuclear elements (LINEs) are ubiquitous transposable elements in higher eukaryotes that have a significant role in shaping genomes, owing to their abundance. Here we report that guanine-rich sequences in the 3′ untranslated regions (UTRs) of hominoid-specific LINE-1 elements are coupled with retrotransposon speciation and contribute to retrotransposition through the formation of G-quadruplex (G4) structures. We demonstrate that stabilization of the G4 motif of a human-specific LINE-1 element by small-molecule ligands stimulates retrotransposition.

AB - Long interspersed nuclear elements (LINEs) are ubiquitous transposable elements in higher eukaryotes that have a significant role in shaping genomes, owing to their abundance. Here we report that guanine-rich sequences in the 3′ untranslated regions (UTRs) of hominoid-specific LINE-1 elements are coupled with retrotransposon speciation and contribute to retrotransposition through the formation of G-quadruplex (G4) structures. We demonstrate that stabilization of the G4 motif of a human-specific LINE-1 element by small-molecule ligands stimulates retrotransposition.

UR - https://www.scopus.com/pages/publications/85010949205

U2 - 10.1038/nsmb.3367

DO - 10.1038/nsmb.3367

M3 - Article

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EP - 247

JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

IS - 3

ER -

G-quadruplex structures within the 3′ UTR of LINE-1 elements stimulate retrotransposition

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