Gaining Weights... and Feeling Good about It!

Ernst Wit, Vilda Purutcuoglu, Lucy O'Donovan, Ximin Zhu

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

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Two problems that dog current microarrays analyses are (i) the relatively arbitrary nature of data preprocessing and (ii) the inability to incorporate spot quality information in inference except by all-or-nothing spot filtering. In this chapter we propose an approach based on using weights to overcome these two problems. The first approach uses weighted p-values to make inference robust to normalization and the second approach uses weighted spot intensity values to improve inference without any filtering.
Original languageEnglish
Title of host publicationEPRINTS-BOOK-TITLE
PublisherUniversity of Groningen, Johann Bernoulli Institute for Mathematics and Computer Science
Number of pages8
Publication statusPublished - 2007

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