Gaining Weights... and Feeling Good about It!

Ernst Wit, Vilda Purutcuoglu, Lucy O'Donovan, Ximin Zhu

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

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Abstract

Two problems that dog current microarrays analyses are (i) the relatively arbitrary nature of data preprocessing and (ii) the inability to incorporate spot quality information in inference except by all-or-nothing spot filtering. In this chapter we propose an approach based on using weights to overcome these two problems. The first approach uses weighted p-values to make inference robust to normalization and the second approach uses weighted spot intensity values to improve inference without any filtering.
Original languageEnglish
Title of host publicationEPRINTS-BOOK-TITLE
PublisherUniversity of Groningen, Johann Bernoulli Institute for Mathematics and Computer Science
Number of pages8
Publication statusPublished - 2007

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