Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal

Jingyue Jia, Aurore Claude-Taupin, Yuexi Gu, Seong Won Choi, Ryan Peters, Bhawana Bissa, Michal H. Mudd, Lee Allers, Sandeep Pallikkuth, Keith A. Lidke, Michelle Salemi, Brett Phinney, Muriel Mari, Fulvio Reggiori, Vojo Deretic*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

88 Citations (Scopus)
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Abstract

Jia et al. show that Galectin-3 recruits ESCRT components to damaged lysosomes for repair and restoration of their function. During sustained lysosomal injury, galectins induce autophagy and lysosomal biogenesis for a staged repair, removal, and replacement program. This response is deployed during damage with neurotoxic tau or Mycobacterium tuberculosis infection.

Original languageEnglish
Pages (from-to)69-+
Number of pages27
JournalDevelopmental Cell
Volume52
Issue number1
Early online date29-Nov-2019
DOIs
Publication statusPublished - 6-Jan-2020

Keywords

  • PROTEIN CONJUGATION SYSTEM
  • ULK1 COMPLEX
  • AUTOPHAGOSOME FORMATION
  • REGULATE AUTOPHAGY
  • DAMAGED LYSOSOMES
  • ESCRT MACHINERY
  • MEMBRANE
  • MTOR
  • RECRUITMENT
  • MECHANISM

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