Gas chromatography-mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients

Mariska Y. M. Peeters; Hiltjo Kuiper; Ben Greijdanus; Joukje van der Naalt; Catherijne A. J. Knibbe; Donald R. A. Uges

doi:10.1016/j.jchromb.2007.01.001

Gas chromatography-mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients

Mariska Y. M. Peeters^*
, Hiltjo Kuiper
, Ben Greijdanus
, Joukje van der Naalt
, Catherijne A. J. Knibbe
, Donald R. A. Uges

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

Abstract

A sensitive gas chromatography-mass spectrometry method for measuring propofol in cerebrospinal fluid is described, validated and applied to four patients after traumatic brain injury. The limit of quantitation was 2 mu g/L using a volume of 0.5 mL. The inter- and intra-assay coefficients of variation were 5.9 and 5.1%, respectively. The assay covers the linear concentration range of 2-50 mu g/L, which is relevant in clinical pharmacokinetic studies when propofol is used in the Intensive Care Unit as a sedative agent or to lower the intracranial pressure. (c) 2007 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	635-639
Number of pages	5
Journal	Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
Volume	852
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jchromb.2007.01.001
Publication status	Published - 1-Jun-2007

Keywords

propofol
CSF
GC-MS
HUMAN PLASMA
BLOOD
QUANTITATION
EXTRACTION
ANESTHESIA
INFUSION
SAMPLES
HPLC

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Gas chromatography-mass spectrometric assay for propofol in cerebrospinal
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Peeters, M. Y. M., Kuiper, H., Greijdanus, B., van der Naalt, J., Knibbe, C. A. J., & Uges, D. R. A. (2007). Gas chromatography-mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 852(1-2), 635-639. https://doi.org/10.1016/j.jchromb.2007.01.001

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title = "Gas chromatography-mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients",

abstract = "A sensitive gas chromatography-mass spectrometry method for measuring propofol in cerebrospinal fluid is described, validated and applied to four patients after traumatic brain injury. The limit of quantitation was 2 mu g/L using a volume of 0.5 mL. The inter- and intra-assay coefficients of variation were 5.9 and 5.1\%, respectively. The assay covers the linear concentration range of 2-50 mu g/L, which is relevant in clinical pharmacokinetic studies when propofol is used in the Intensive Care Unit as a sedative agent or to lower the intracranial pressure. (c) 2007 Elsevier B.V. All rights reserved.",

keywords = "propofol, CSF, GC-MS, HUMAN PLASMA, BLOOD, QUANTITATION, EXTRACTION, ANESTHESIA, INFUSION, SAMPLES, HPLC",

author = "Peeters, \{Mariska Y. M.\} and Hiltjo Kuiper and Ben Greijdanus and \{van der Naalt\}, Joukje and Knibbe, \{Catherijne A. J.\} and Uges, \{Donald R. A.\}",

year = "2007",

month = jun,

day = "1",

doi = "10.1016/j.jchromb.2007.01.001",

language = "English",

volume = "852",

pages = "635--639",

journal = "Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences",

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number = "1-2",

}

Gas chromatography-mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients. / Peeters, Mariska Y. M.; Kuiper, Hiltjo; Greijdanus, Ben et al.
In: Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, Vol. 852, No. 1-2, 01.06.2007, p. 635-639.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Gas chromatography-mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients

AU - Peeters, Mariska Y. M.

AU - Kuiper, Hiltjo

AU - Greijdanus, Ben

AU - van der Naalt, Joukje

AU - Knibbe, Catherijne A. J.

AU - Uges, Donald R. A.

PY - 2007/6/1

Y1 - 2007/6/1

N2 - A sensitive gas chromatography-mass spectrometry method for measuring propofol in cerebrospinal fluid is described, validated and applied to four patients after traumatic brain injury. The limit of quantitation was 2 mu g/L using a volume of 0.5 mL. The inter- and intra-assay coefficients of variation were 5.9 and 5.1%, respectively. The assay covers the linear concentration range of 2-50 mu g/L, which is relevant in clinical pharmacokinetic studies when propofol is used in the Intensive Care Unit as a sedative agent or to lower the intracranial pressure. (c) 2007 Elsevier B.V. All rights reserved.

AB - A sensitive gas chromatography-mass spectrometry method for measuring propofol in cerebrospinal fluid is described, validated and applied to four patients after traumatic brain injury. The limit of quantitation was 2 mu g/L using a volume of 0.5 mL. The inter- and intra-assay coefficients of variation were 5.9 and 5.1%, respectively. The assay covers the linear concentration range of 2-50 mu g/L, which is relevant in clinical pharmacokinetic studies when propofol is used in the Intensive Care Unit as a sedative agent or to lower the intracranial pressure. (c) 2007 Elsevier B.V. All rights reserved.

KW - propofol

KW - CSF

KW - GC-MS

KW - HUMAN PLASMA

KW - BLOOD

KW - QUANTITATION

KW - EXTRACTION

KW - ANESTHESIA

KW - INFUSION

KW - SAMPLES

KW - HPLC

U2 - 10.1016/j.jchromb.2007.01.001

DO - 10.1016/j.jchromb.2007.01.001

M3 - Article

SN - 1570-0232

VL - 852

SP - 635

EP - 639

JO - Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences

JF - Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences

IS - 1-2

ER -

Gas chromatography-mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients

Abstract

Keywords

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