Abstract
A simple Ugi tetrazole multicomponent reaction allows the synthesis of a novel macrocyclic cyclen derivative with four appendant tetrazole arms in just two steps in excellent yields. This ligand, called TEMDO, turns out to have a high complexation affinity with lanthanoid metals. Here we describe the design, synthesis, solid-state structure, binding constant, and some MRI applications of the Gd-TEMDO complex as the first example of a congeneric family of oligo-amino tetrazoles.
| Original language | English |
|---|---|
| Pages (from-to) | 7352-7356 |
| Number of pages | 5 |
| Journal | Chemistry |
| Volume | 22 |
| Issue number | 22 |
| DOIs | |
| Publication status | Published - 23-May-2016 |
Keywords
- gadolinium
- macrocyclic ligands
- magnetic resonance imaging
- multicomponent reactions
- oligoamino tetrazole
- MULTICOMPONENT REACTIONS
- LANTHANIDE COMPLEXES
- WATER EXCHANGE
- NOBEL-LECTURE
- CHEMISTRY
- SPECTROSCOPY
- DERIVATIVES
- CYCLEN
- ACID
- SIZE
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CCDC 1039908: Experimental Crystal Structure Determination
Boltjes, A. (Contributor), Shrinidhi, A. (Contributor), van de Kolk, K. (Contributor), Herdtweck, E. (Contributor) & Dömling, A. (Contributor), University of Groningen, 17-Dec-2014
DOI: 10.5517/ccdc.csd.cc13x3fk
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