Gender incongruence and gender dysphoria in childhood and adolescence-current insights in diagnostics, management, and follow-up

Hedi van der Grinten*, Chris Verhaak, Thomas Steensma, Tim Middelberg, Joep Roeffen, Daniel Klink

*Corresponding author for this work

    Research output: Contribution to journalReview articleAcademicpeer-review

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    Gender incongruence (GI) is defined as a condition in which the gender identity of a person does not align with the gender assigned at birth. Awareness and more social acceptance have paved the way for early medical intervention about two decades ago and are now part of good clinical practice although much robust data is lacking. Medical and mental treatment in adolescents with GI is complex and is recommended to take place within a team of mental health professionals, psychiatrists, endocrinologists, and other healthcare providers. The somatic treatment generally consists of the use of GnRH analogues to prevent the progression of biological puberty and subsequently gender-affirming hormonal treatment to develop sex characteristics of the self-identified gender and surgical procedures. However to optimize treatment regimens, long-term follow-up and additional studies are still needed. What is known

    The prevalence of gender dysphoria increased significantly in the past years and can lead to significant complaints and burdens especially during puberty.

    Pubertal suppression and gender-affirmed treatment can be effectively used in adolescence with gender dysphoria.

    What is new

    Transgender mental and medical healthcare is a long-lasting process during which not only the child/adolescent with GI but also their parents/family have to be counseled in making choices about their social, medical, and legal transitions.

    There are an increasing number of transgender persons defining as nonbinary. Therefore, an individualized approach by an experienced team is necessary.

    Original languageEnglish
    Pages (from-to)1349-1357
    Number of pages9
    JournalEuropean Journal of Pediatrics
    Early online date18-Dec-2020
    Publication statusPublished - May-2021


    • Gender incongruence
    • Gender dysphoria
    • Transgender care
    • Pubertal suppression
    • Gender-affirming treatment
    • MASS

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