Gene expression in placentas from nondiabetic women giving birth to large for gestational age infants

F. Ahlsson*, H. Åkerud, D. Schijven, J. Olivier, I. Sundstrom-Poromaa

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Gestational diabetes, obesity, and excessive weight gain are known independent risk factors for the birth of a large for gestational age (LGA) infant. However, only 1 of the 10 infants born LGA is born by mothers with diabetes or obesity. Thus, the aim of the present study was to compare placental gene expression between healthy, nondiabetic mothers (n = 22) giving birth to LGA infants and body mass index-matched mothers (n = 24) giving birth to appropriate for gestational age infants. In the whole gene expression analysis, only 29 genes were found to be differently expressed in LGA placentas. Top upregulated genes included insulin-like growth factor binding protein 1, aminolevulinate synthase 2, and prolactin, whereas top downregulated genes comprised leptin, gametocyte-specific factor 1, and collagen type XVII 1. Two enriched gene networks were identified, namely, (1) lipid metabolism, small molecule biochemistry, and organismal development and (2) cellular development, cellular growth, proliferation, and tumor morphology.

Original languageEnglish
Pages (from-to)1281-1288
Number of pages8
JournalReproductive Sciences
Volume22
Issue number10
DOIs
Publication statusPublished - Oct-2015

Keywords

  • large for gestational age
  • placental gene expression
  • microarray
  • leptin
  • and prolactin
  • INTRAUTERINE GROWTH RESTRICTION
  • STABILIZING PROTEIN AHSP
  • FETAL-GROWTH
  • MICROARRAY ANALYSIS
  • INSULIN-RESISTANCE
  • DIABETES-MELLITUS
  • CORD BLOOD
  • PREGNANCY
  • LEPTIN
  • ADIPOKINES

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