Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

William J. Young; Najim Lahrouchi; Aaron Isaacs; ThuyVy Duong; Luisa Foco; Farah Ahmed; Jennifer A. Brody; Reem Salman; Raymond Noordam; Jan-Walter Benjamins; Jeffrey Haessler; Leo-Pekka Lyytikäinen; Linda Repetto; Maria Pina Concas; Marten E. van den Berg; Stefan Weiss; Antoine R. Baldassari; Traci M. Bartz; James P. Cook; Daniel S. Evans; Rebecca Freudling; Oliver Hines; Jonas L. Isaksen; Honghuang Lin; Hao Mei; Arden Moscati; Martina Müller-Nurasyid; Casia Nursyifa; Yong Qian; Anne Richmond; Carolina Roselli; Kathleen A. Ryan; Eduardo Tarazona-Santos; Sébastien Thériault; Stefan van Duijvenboden; Helen R. Warren; Jie Yao; Dania Raza; Stefanie Aeschbacher; Gustav Ahlberg; Alvaro Alonso; Laura Andreasen; Joshua C. Bis; Eric Boerwinkle; Archie Campbell; Eulalia Catamo; Massimiliano Cocca; Michael J. Cutler; Dawood Darbar; Alessandro De Grandi; Antonio De Luca; Jun Ding; Christina Ellervik; Patrick T. Ellinor; Stephan B. Felix; Philippe Froguel; Christian Fuchsberger; Martin Gögele; Claus Graff; Mariaelisa Graff; Xiuqing Guo; Torben Hansen; Susan R. Heckbert; Paul L. Huang; Heikki V. Huikuri; Nina Hutri-Kähönen; M.Arfan Ikram; Rebecca D. Jackson; Juhani Junttila; Maryam Kavousi; Jan A. Kors; Thiago P. Leal; Rozenn N. Lemaitre; Henry J. Lin; Lars Lind; Allan Linneberg; Simin Liu; Peter W. MacFarlane; Massimo Mangino; Thomas Meitinger; Massimo Mezzavilla; Pashupati P. Mishra; Rebecca N. Mitchell; Nina Mononen; May E. Montasser; Alanna C. Morrison; Matthias Nauck; Victor Nauffal; Pau Navarro; Kjell Nikus; Guillaume Pare; Kristen K. Patton; Giulia Pelliccione; Alan Pittman; David J. Porteous; Peter P. Pramstaller; Michael H. Preuss; Olli T. Raitakari; Alexander P. Reiner; Antonio Luiz P. Ribeiro; Kenneth M. Rice; Lorenz Risch; David Schlessinger; Ulrich Schotten; Claudia Schurmann; Xia Shen; M.Benjamin Shoemaker; Gianfranco Sinagra; Moritz F. Sinner; Elsayed Z. Soliman; Monika Stoll; Konstantin Strauch; Kirill Tarasov; Kent D. Taylor; Andrew Tinker; Stella Trompet; André Uitterlinden; Uwe Völker; Henry Völzke; Melanie Waldenberger; Lu-Chen Weng; Eric A. Whitsel; James G. Wilson; Christy L. Avery; David Conen; Adolfo Correa; Francesco Cucca; Marcus Dörr; Sina A. Gharib; Giorgia Girotto; Niels Grarup; Caroline Hayward; Yalda Jamshidi; Marjo-Riitta Järvelin; J.Wouter Jukema; Stefan Kääb; Mika Kähönen; Jørgen K. Kanters; Charles Kooperberg; Terho Lehtimäki; Maria Fernanda Lima-Costa; Yongmei Liu; Ruth J.F. Loos; Steven A. Lubitz; Dennis O. Mook-Kanamori; Andrew P. Morris; Jeffrey R. O’Connell; Morten Salling Olesen; Michele Orini; Sandosh Padmanabhan; Cristian Pattaro; Annette Peters; Bruce M. Psaty; Jerome I. Rotter; Bruno Stricker; Pim van der Harst; Cornelia M. van Duijn; Niek Verweij; James F. Wilson; Dan E. Arking; Julia Ramirez; Pier D. Lambiase; Nona Sotoodehnia; Borbala Mifsud; Christopher Newton-Cheh; Patricia B. Munroe

doi:10.1101/2021.11.04.21265866

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

William J. Young, Najim Lahrouchi, Aaron Isaacs, ThuyVy Duong, Luisa Foco, Farah Ahmed, Jennifer A. Brody, Reem Salman, Raymond Noordam, Jan-Walter Benjamins, Jeffrey Haessler, Leo-Pekka Lyytikäinen, Linda Repetto, Maria Pina Concas, Marten E. van den Berg, Stefan Weiss, Antoine R. Baldassari, Traci M. Bartz, James P. Cook, Daniel S. EvansRebecca Freudling, Oliver Hines, Jonas L. Isaksen, Honghuang Lin, Hao Mei, Arden Moscati, Martina Müller-Nurasyid, Casia Nursyifa, Yong Qian, Anne Richmond, Carolina Roselli, Kathleen A. Ryan, Eduardo Tarazona-Santos, Sébastien Thériault, Stefan van Duijvenboden, Helen R. Warren, Jie Yao, Dania Raza, Stefanie Aeschbacher, Gustav Ahlberg, Alvaro Alonso, Laura Andreasen, Joshua C. Bis, Eric Boerwinkle, Archie Campbell, Eulalia Catamo, Massimiliano Cocca, Michael J. Cutler, Dawood Darbar, Alessandro De Grandi, Antonio De Luca, Jun Ding, Christina Ellervik, Patrick T. Ellinor, Stephan B. Felix, Philippe Froguel, Christian Fuchsberger, Martin Gögele, Claus Graff, Mariaelisa Graff, Xiuqing Guo, Torben Hansen, Susan R. Heckbert, Paul L. Huang, Heikki V. Huikuri, Nina Hutri-Kähönen, M.Arfan Ikram, Rebecca D. Jackson, Juhani Junttila, Maryam Kavousi, Jan A. Kors, Thiago P. Leal, Rozenn N. Lemaitre, Henry J. Lin, Lars Lind, Allan Linneberg, Simin Liu, Peter W. MacFarlane, Massimo Mangino, Thomas Meitinger, Massimo Mezzavilla, Pashupati P. Mishra, Rebecca N. Mitchell, Nina Mononen, May E. Montasser, Alanna C. Morrison, Matthias Nauck, Victor Nauffal, Pau Navarro, Kjell Nikus, Guillaume Pare, Kristen K. Patton, Giulia Pelliccione, Alan Pittman, David J. Porteous, Peter P. Pramstaller, Michael H. Preuss, Olli T. Raitakari, Alexander P. Reiner, Antonio Luiz P. Ribeiro, Kenneth M. Rice, Lorenz Risch, David Schlessinger, Ulrich Schotten, Claudia Schurmann, Xia Shen, M.Benjamin Shoemaker, Gianfranco Sinagra, Moritz F. Sinner, Elsayed Z. Soliman, Monika Stoll, Konstantin Strauch, Kirill Tarasov, Kent D. Taylor, Andrew Tinker, Stella Trompet, André Uitterlinden, Uwe Völker, Henry Völzke, Melanie Waldenberger, Lu-Chen Weng, Eric A. Whitsel, James G. Wilson, Christy L. Avery, David Conen, Adolfo Correa, Francesco Cucca, Marcus Dörr, Sina A. Gharib, Giorgia Girotto, Niels Grarup, Caroline Hayward, Yalda Jamshidi, Marjo-Riitta Järvelin, J.Wouter Jukema, Stefan Kääb, Mika Kähönen, Jørgen K. Kanters, Charles Kooperberg, Terho Lehtimäki, Maria Fernanda Lima-Costa, Yongmei Liu, Ruth J.F. Loos, Steven A. Lubitz, Dennis O. Mook-Kanamori, Andrew P. Morris, Jeffrey R. O’Connell, Morten Salling Olesen, Michele Orini, Sandosh Padmanabhan, Cristian Pattaro, Annette Peters, Bruce M. Psaty, Jerome I. Rotter, Bruno Stricker, Pim van der Harst, Cornelia M. van Duijn, Niek Verweij, James F. Wilson, Dan E. Arking, Julia Ramirez, Pier D. Lambiase, Nona Sotoodehnia, Borbala Mifsud, Christopher Newton-Cheh, Patricia B. Munroe

Cardiovascular Centre (CVC)

Research output: Working paper › Preprint › Academic

129 Downloads (Pure)

Original language	English
Publisher	MedRxiv
DOIs	https://doi.org/10.1101/2021.11.04.21265866
Publication status	Published - 4-Nov-2021

Access to Document

10.1101/2021.11.04.21265866

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarizationFinal publisher's version, 3.99 MBLicence: Taverne

Handle.net

Persistent link

Cite this

Young, W. J., Lahrouchi, N., Isaacs, A., Duong, T., Foco, L., Ahmed, F., Brody, J. A., Salman, R., Noordam, R., Benjamins, J.-W., Haessler, J., Lyytikäinen, L.-P., Repetto, L., Concas, M. P., Berg, M. E. V. D., Weiss, S., Baldassari, A. R., Bartz, T. M., Cook, J. P., ... Munroe, P. B. (2021). Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization. MedRxiv. https://doi.org/10.1101/2021.11.04.21265866

@techreport{27d8c7a14fad441381c0cbe315102793,

title = "Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization",

author = "Young, {William J.} and Najim Lahrouchi and Aaron Isaacs and ThuyVy Duong and Luisa Foco and Farah Ahmed and Brody, {Jennifer A.} and Reem Salman and Raymond Noordam and Jan-Walter Benjamins and Jeffrey Haessler and Leo-Pekka Lyytik{\"a}inen and Linda Repetto and Concas, {Maria Pina} and Berg, {Marten E. van den} and Stefan Weiss and Baldassari, {Antoine R.} and Bartz, {Traci M.} and Cook, {James P.} and Evans, {Daniel S.} and Rebecca Freudling and Oliver Hines and Isaksen, {Jonas L.} and Honghuang Lin and Hao Mei and Arden Moscati and Martina M{\"u}ller-Nurasyid and Casia Nursyifa and Yong Qian and Anne Richmond and Carolina Roselli and Ryan, {Kathleen A.} and Eduardo Tarazona-Santos and S{\'e}bastien Th{\'e}riault and Duijvenboden, {Stefan van} and Warren, {Helen R.} and Jie Yao and Dania Raza and Stefanie Aeschbacher and Gustav Ahlberg and Alvaro Alonso and Laura Andreasen and Bis, {Joshua C.} and Eric Boerwinkle and Archie Campbell and Eulalia Catamo and Massimiliano Cocca and Cutler, {Michael J.} and Dawood Darbar and Grandi, {Alessandro De} and Luca, {Antonio De} and Jun Ding and Christina Ellervik and Ellinor, {Patrick T.} and Felix, {Stephan B.} and Philippe Froguel and Christian Fuchsberger and Martin G{\"o}gele and Claus Graff and Mariaelisa Graff and Xiuqing Guo and Torben Hansen and Heckbert, {Susan R.} and Huang, {Paul L.} and Huikuri, {Heikki V.} and Nina Hutri-K{\"a}h{\"o}nen and M.Arfan Ikram and Jackson, {Rebecca D.} and Juhani Junttila and Maryam Kavousi and Kors, {Jan A.} and Leal, {Thiago P.} and Lemaitre, {Rozenn N.} and Lin, {Henry J.} and Lars Lind and Allan Linneberg and Simin Liu and MacFarlane, {Peter W.} and Massimo Mangino and Thomas Meitinger and Massimo Mezzavilla and Mishra, {Pashupati P.} and Mitchell, {Rebecca N.} and Nina Mononen and Montasser, {May E.} and Morrison, {Alanna C.} and Matthias Nauck and Victor Nauffal and Pau Navarro and Kjell Nikus and Guillaume Pare and Patton, {Kristen K.} and Giulia Pelliccione and Alan Pittman and Porteous, {David J.} and Pramstaller, {Peter P.} and Preuss, {Michael H.} and Raitakari, {Olli T.} and Reiner, {Alexander P.} and Ribeiro, {Antonio Luiz P.} and Rice, {Kenneth M.} and Lorenz Risch and David Schlessinger and Ulrich Schotten and Claudia Schurmann and Xia Shen and M.Benjamin Shoemaker and Gianfranco Sinagra and Sinner, {Moritz F.} and Soliman, {Elsayed Z.} and Monika Stoll and Konstantin Strauch and Kirill Tarasov and Taylor, {Kent D.} and Andrew Tinker and Stella Trompet and Andr{\'e} Uitterlinden and Uwe V{\"o}lker and Henry V{\"o}lzke and Melanie Waldenberger and Lu-Chen Weng and Whitsel, {Eric A.} and Wilson, {James G.} and Avery, {Christy L.} and David Conen and Adolfo Correa and Francesco Cucca and Marcus D{\"o}rr and Gharib, {Sina A.} and Giorgia Girotto and Niels Grarup and Caroline Hayward and Yalda Jamshidi and Marjo-Riitta J{\"a}rvelin and J.Wouter Jukema and Stefan K{\"a}{\"a}b and Mika K{\"a}h{\"o}nen and Kanters, {J{\o}rgen K.} and Charles Kooperberg and Terho Lehtim{\"a}ki and Lima-Costa, {Maria Fernanda} and Yongmei Liu and Loos, {Ruth J.F.} and Lubitz, {Steven A.} and Mook-Kanamori, {Dennis O.} and Morris, {Andrew P.} and O{\textquoteright}Connell, {Jeffrey R.} and Olesen, {Morten Salling} and Michele Orini and Sandosh Padmanabhan and Cristian Pattaro and Annette Peters and Psaty, {Bruce M.} and Rotter, {Jerome I.} and Bruno Stricker and Harst, {Pim van der} and Duijn, {Cornelia M. van} and Niek Verweij and Wilson, {James F.} and Arking, {Dan E.} and Julia Ramirez and Lambiase, {Pier D.} and Nona Sotoodehnia and Borbala Mifsud and Christopher Newton-Cheh and Munroe, {Patricia B.}",

year = "2021",

month = nov,

day = "4",

doi = "10.1101/2021.11.04.21265866",

language = "English",

publisher = "MedRxiv",

type = "WorkingPaper",

institution = "MedRxiv",

}

Young, WJ, Lahrouchi, N, Isaacs, A, Duong, T, Foco, L, Ahmed, F, Brody, JA, Salman, R, Noordam, R, Benjamins, J-W, Haessler, J, Lyytikäinen, L-P, Repetto, L, Concas, MP, Berg, MEVD, Weiss, S, Baldassari, AR, Bartz, TM, Cook, JP, Evans, DS, Freudling, R, Hines, O, Isaksen, JL, Lin, H, Mei, H, Moscati, A, Müller-Nurasyid, M, Nursyifa, C, Qian, Y, Richmond, A, Roselli, C, Ryan, KA, Tarazona-Santos, E, Thériault, S, Duijvenboden, SV, Warren, HR, Yao, J, Raza, D, Aeschbacher, S, Ahlberg, G, Alonso, A, Andreasen, L, Bis, JC, Boerwinkle, E, Campbell, A, Catamo, E, Cocca, M, Cutler, MJ, Darbar, D, Grandi, AD, Luca, AD, Ding, J, Ellervik, C, Ellinor, PT, Felix, SB, Froguel, P, Fuchsberger, C, Gögele, M, Graff, C, Graff, M, Guo, X, Hansen, T, Heckbert, SR, Huang, PL, Huikuri, HV, Hutri-Kähönen, N, Ikram, MA, Jackson, RD, Junttila, J, Kavousi, M, Kors, JA, Leal, TP, Lemaitre, RN, Lin, HJ, Lind, L, Linneberg, A, Liu, S, MacFarlane, PW, Mangino, M, Meitinger, T, Mezzavilla, M, Mishra, PP, Mitchell, RN, Mononen, N, Montasser, ME, Morrison, AC, Nauck, M, Nauffal, V, Navarro, P, Nikus, K, Pare, G, Patton, KK, Pelliccione, G, Pittman, A, Porteous, DJ, Pramstaller, PP, Preuss, MH, Raitakari, OT, Reiner, AP, Ribeiro, ALP, Rice, KM, Risch, L, Schlessinger, D, Schotten, U, Schurmann, C, Shen, X, Shoemaker, MB, Sinagra, G, Sinner, MF, Soliman, EZ, Stoll, M, Strauch, K, Tarasov, K, Taylor, KD, Tinker, A, Trompet, S, Uitterlinden, A, Völker, U, Völzke, H, Waldenberger, M, Weng, L-C, Whitsel, EA, Wilson, JG, Avery, CL, Conen, D, Correa, A, Cucca, F, Dörr, M, Gharib, SA, Girotto, G, Grarup, N, Hayward, C, Jamshidi, Y, Järvelin, M-R, Jukema, JW, Kääb, S, Kähönen, M, Kanters, JK, Kooperberg, C, Lehtimäki, T, Lima-Costa, MF, Liu, Y, Loos, RJF, Lubitz, SA, Mook-Kanamori, DO, Morris, AP, O’Connell, JR, Olesen, MS, Orini, M, Padmanabhan, S, Pattaro, C, Peters, A, Psaty, BM, Rotter, JI, Stricker, B, Harst, PVD, Duijn, CMV, Verweij, N, Wilson, JF, Arking, DE, Ramirez, J, Lambiase, PD, Sotoodehnia, N, Mifsud, B, Newton-Cheh, C & Munroe, PB 2021 'Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization' MedRxiv. https://doi.org/10.1101/2021.11.04.21265866

TY - UNPB

T1 - Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

AU - Young, William J.

AU - Lahrouchi, Najim

AU - Isaacs, Aaron

AU - Duong, ThuyVy

AU - Foco, Luisa

AU - Ahmed, Farah

AU - Brody, Jennifer A.

AU - Salman, Reem

AU - Noordam, Raymond

AU - Benjamins, Jan-Walter

AU - Haessler, Jeffrey

AU - Lyytikäinen, Leo-Pekka

AU - Repetto, Linda

AU - Concas, Maria Pina

AU - Berg, Marten E. van den

AU - Weiss, Stefan

AU - Baldassari, Antoine R.

AU - Bartz, Traci M.

AU - Cook, James P.

AU - Evans, Daniel S.

AU - Freudling, Rebecca

AU - Hines, Oliver

AU - Isaksen, Jonas L.

AU - Lin, Honghuang

AU - Mei, Hao

AU - Moscati, Arden

AU - Müller-Nurasyid, Martina

AU - Nursyifa, Casia

AU - Qian, Yong

AU - Richmond, Anne

AU - Roselli, Carolina

AU - Ryan, Kathleen A.

AU - Tarazona-Santos, Eduardo

AU - Thériault, Sébastien

AU - Duijvenboden, Stefan van

AU - Warren, Helen R.

AU - Yao, Jie

AU - Raza, Dania

AU - Aeschbacher, Stefanie

AU - Ahlberg, Gustav

AU - Alonso, Alvaro

AU - Andreasen, Laura

AU - Bis, Joshua C.

AU - Boerwinkle, Eric

AU - Campbell, Archie

AU - Catamo, Eulalia

AU - Cocca, Massimiliano

AU - Cutler, Michael J.

AU - Darbar, Dawood

AU - Grandi, Alessandro De

AU - Luca, Antonio De

AU - Ding, Jun

AU - Ellervik, Christina

AU - Ellinor, Patrick T.

AU - Felix, Stephan B.

AU - Froguel, Philippe

AU - Fuchsberger, Christian

AU - Gögele, Martin

AU - Graff, Claus

AU - Graff, Mariaelisa

AU - Guo, Xiuqing

AU - Hansen, Torben

AU - Heckbert, Susan R.

AU - Huang, Paul L.

AU - Huikuri, Heikki V.

AU - Hutri-Kähönen, Nina

AU - Ikram, M.Arfan

AU - Jackson, Rebecca D.

AU - Junttila, Juhani

AU - Kavousi, Maryam

AU - Kors, Jan A.

AU - Leal, Thiago P.

AU - Lemaitre, Rozenn N.

AU - Lin, Henry J.

AU - Lind, Lars

AU - Linneberg, Allan

AU - Liu, Simin

AU - MacFarlane, Peter W.

AU - Mangino, Massimo

AU - Meitinger, Thomas

AU - Mezzavilla, Massimo

AU - Mishra, Pashupati P.

AU - Mitchell, Rebecca N.

AU - Mononen, Nina

AU - Montasser, May E.

AU - Morrison, Alanna C.

AU - Nauck, Matthias

AU - Nauffal, Victor

AU - Navarro, Pau

AU - Nikus, Kjell

AU - Pare, Guillaume

AU - Patton, Kristen K.

AU - Pelliccione, Giulia

AU - Pittman, Alan

AU - Porteous, David J.

AU - Pramstaller, Peter P.

AU - Preuss, Michael H.

AU - Raitakari, Olli T.

AU - Reiner, Alexander P.

AU - Ribeiro, Antonio Luiz P.

AU - Rice, Kenneth M.

AU - Risch, Lorenz

AU - Schlessinger, David

AU - Schotten, Ulrich

AU - Schurmann, Claudia

AU - Shen, Xia

AU - Shoemaker, M.Benjamin

AU - Sinagra, Gianfranco

AU - Sinner, Moritz F.

AU - Soliman, Elsayed Z.

AU - Stoll, Monika

AU - Strauch, Konstantin

AU - Tarasov, Kirill

AU - Taylor, Kent D.

AU - Tinker, Andrew

AU - Trompet, Stella

AU - Uitterlinden, André

AU - Völker, Uwe

AU - Völzke, Henry

AU - Waldenberger, Melanie

AU - Weng, Lu-Chen

AU - Whitsel, Eric A.

AU - Wilson, James G.

AU - Avery, Christy L.

AU - Conen, David

AU - Correa, Adolfo

AU - Cucca, Francesco

AU - Dörr, Marcus

AU - Gharib, Sina A.

AU - Girotto, Giorgia

AU - Grarup, Niels

AU - Hayward, Caroline

AU - Jamshidi, Yalda

AU - Järvelin, Marjo-Riitta

AU - Jukema, J.Wouter

AU - Kääb, Stefan

AU - Kähönen, Mika

AU - Kanters, Jørgen K.

AU - Kooperberg, Charles

AU - Lehtimäki, Terho

AU - Lima-Costa, Maria Fernanda

AU - Liu, Yongmei

AU - Loos, Ruth J.F.

AU - Lubitz, Steven A.

AU - Mook-Kanamori, Dennis O.

AU - Morris, Andrew P.

AU - O’Connell, Jeffrey R.

AU - Olesen, Morten Salling

AU - Orini, Michele

AU - Padmanabhan, Sandosh

AU - Pattaro, Cristian

AU - Peters, Annette

AU - Psaty, Bruce M.

AU - Rotter, Jerome I.

AU - Stricker, Bruno

AU - Harst, Pim van der

AU - Duijn, Cornelia M. van

AU - Verweij, Niek

AU - Wilson, James F.

AU - Arking, Dan E.

AU - Ramirez, Julia

AU - Lambiase, Pier D.

AU - Sotoodehnia, Nona

AU - Mifsud, Borbala

AU - Newton-Cheh, Christopher

AU - Munroe, Patricia B.

PY - 2021/11/4

Y1 - 2021/11/4

U2 - 10.1101/2021.11.04.21265866

DO - 10.1101/2021.11.04.21265866

M3 - Preprint

BT - Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

PB - MedRxiv

ER -