Genetic and environmental determinants of blood pressure: the role of obesity and the autonomic nervous system

Tengfei Man

    Research output: ThesisThesis fully internal (DIV)

    299 Downloads (Pure)

    Abstract

    Cardiac autonomic dysfunction and obesity may play a role in the development of higher blood pressure, however the underlying physiological mechanisms are not yet fully understood. This thesis aimed to unravel the factors that influence the cardiac autonomic nervous system (ANS) and to determine the genetic and environmental overlap of blood pressure with cardiac ANS and obesity measures in three large population-based databases. First, I found that age and sex were the most important determinants of the cardiac ANS measures, explaining about 16% of the inter-individual differences. We also established reference values across difference age groups and showed that the function of the cardiac ANS declined substantially with age and that women had a better cardiac ANS function than men. Second, I confirmed that all cardiac ANS and obesity indices were heritable and showed that they significantly correlated with blood pressure. Third, we found significant genetic correlations of the cardiac ANS and obesity indices with blood pressure. In conclusion, our work provides robust evidence that blood pressure is genetically correlated with cardiac ANS and obesity which will drive the scientific efforts to identify genes responsible for these shared genetic influences.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Snieder, Harold, Supervisor
    • Riese, Harriette, Supervisor
    • Nolte, Ilja, Co-supervisor
    Award date14-Dec-2022
    Place of Publication[Groningen]
    Publisher
    DOIs
    Publication statusPublished - 2022

    Fingerprint

    Dive into the research topics of 'Genetic and environmental determinants of blood pressure: the role of obesity and the autonomic nervous system'. Together they form a unique fingerprint.

    Cite this