Genetic and Environmental Influences on Pro-Inflammatory Monocytes in Bipolar Disorder A Twin Study

Roos C. Padmos, G. Caroline M. Van Baal, Ronald Vonk, Annemarie J. M. Wijkhuijs, Rene S. Kahn, Willem A. Nolen, Hemmo A. Drexhage*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Abstract

Context: A monocyte pro-inflammatory state has previously been reported in bipolar disorder (BD).

Objective: To determine the contribution of genetic and environmental influences on the association between monocyte pro- inflammatory state and BD.

Design: A quantitative polymerase chain reaction case-control study of monocytes in bipolar twins. Determination of the influence of additive genetic, common, and unique environmental factors by structural equation modeling (ACE).

Setting: Dutch academic research center.

Participants: Eighteen monozygotic BD twin pairs, 23 dizygotic BD twin pairs, and 18 monozygotic and 16 dizygotic healthy twin pairs. Main Outcome Measures: Expression levels of monocytes in the previously reported coherent set of 19 genes (signature) reflecting the pro- inflammatory state.

Results: The familial occurrence of the association between the monocyte pro- inflammatory gene-expression signature and BDfound in the within-trait/cross-twin correlations (twin correlations) was due to shared environmental factors (ie, both monozygotic and dizygotic ratios in twin correlations approximated 1; ACE modeling data: 94% [95% confidence interval, 53%-99%] explained by common [shared] environmental factors). Although most individual signature genes followed this pattern, there was a small subcluster of genes in which genetic influences could dominate.

Conclusion: The association of the monocyte proinflammatory state with BD is primarily the result of a common shared environmental factor.

Original languageEnglish
Pages (from-to)957-+
Number of pages15
JournalArchives of General Psychiatry
Volume66
Issue number9
Publication statusPublished - Sep-2009

Keywords

  • PITUITARY-ADRENAL AXIS
  • RESIDUAL DISEASE DETECTION
  • POLYMERASE-CHAIN-REACTION
  • MENTAL-HEALTH SURVEY
  • IMMUNE-RESPONSE
  • GENERAL-POPULATION
  • MAJOR DEPRESSION
  • MOOD DISORDERS
  • CANCER PROGRAM
  • BIRTH-WEIGHT

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