Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content

Lianmin Chen; Kiki Schraa; Inge C L van den Munckhof; Rob Ter Horst; Martijn Koehorst; Martijn van Faassen; Claude van der Ley; Marwah Doestzada; Daria V Zhernakova; Alexander Kurilshikov; Vincent W Bloks; Albert K Groen; Human Functional Genomics Project; Niels P Riksen; Joost H W Rutten; Leo A B Joosten; Cisca Wijmenga; Alexandra Zhernakova; Mihai G Netea; Jingyuan Fu; Folkert Kuipers

doi:10.1016/j.celrep.2020.108212

Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content

Lianmin Chen, Kiki Schraa, Inge C L van den Munckhof, Rob Ter Horst, Martijn Koehorst, Martijn van Faassen, Claude van der Ley, Marwah Doestzada, Daria V Zhernakova, Alexander Kurilshikov, Vincent W Bloks, Albert K Groen, Human Functional Genomics Project, Niels P Riksen, Joost H W Rutten, Leo A B Joosten, Cisca Wijmenga, Alexandra Zhernakova, Mihai G Netea, Jingyuan FuFolkert Kuipers

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Bile acids (BAs) have been implicated in obesity-related conditions such as NAFLD and hyperlipidemia. Different human BAs exert variable biological activities. Chen et al. define genetic and microbial associations to plasma and fecal BA concentrations and composition in persons with obesity and establish their relationships with liver fat and lipid phenotypes.

Original language	English
Article number	108212
Number of pages	13
Journal	Cell reports
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2020.108212
Publication status	Published - 6-Oct-2020

Keywords

HUMANS
HYPERTRIGLYCERIDEMIA
MICE

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Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat ContentFinal publisher's version, 3.11 MBLicence: CC BY

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Chen, L., Schraa, K., van den Munckhof, I. C. L., Ter Horst, R., Koehorst, M., van Faassen, M., van der Ley, C., Doestzada, M., Zhernakova, D. V., Kurilshikov, A., Bloks, V. W., Groen, A. K., Human Functional Genomics Project, Riksen, N. P., Rutten, J. H. W., Joosten, L. A. B., Wijmenga, C., Zhernakova, A., Netea, M. G., ... Kuipers, F. (2020). Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content. Cell reports, 33(1), [108212]. https://doi.org/10.1016/j.celrep.2020.108212

Chen, Lianmin ; Schraa, Kiki ; van den Munckhof, Inge C L ; Ter Horst, Rob ; Koehorst, Martijn ; van Faassen, Martijn ; van der Ley, Claude ; Doestzada, Marwah ; Zhernakova, Daria V ; Kurilshikov, Alexander ; Bloks, Vincent W ; Groen, Albert K ; Human Functional Genomics Project ; Riksen, Niels P ; Rutten, Joost H W ; Joosten, Leo A B ; Wijmenga, Cisca ; Zhernakova, Alexandra ; Netea, Mihai G ; Fu, Jingyuan ; Kuipers, Folkert. / Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content. In: Cell reports. 2020 ; Vol. 33, No. 1.

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title = "Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content",

abstract = "Bile acids (BAs) have been implicated in obesity-related conditions such as NAFLD and hyperlipidemia. Different human BAs exert variable biological activities. Chen et al. define genetic and microbial associations to plasma and fecal BA concentrations and composition in persons with obesity and establish their relationships with liver fat and lipid phenotypes.",

keywords = "HUMANS, HYPERTRIGLYCERIDEMIA, MICE",

author = "Lianmin Chen and Kiki Schraa and {van den Munckhof}, {Inge C L} and {Ter Horst}, Rob and Martijn Koehorst and {van Faassen}, Martijn and {van der Ley}, Claude and Marwah Doestzada and Zhernakova, {Daria V} and Alexander Kurilshikov and Bloks, {Vincent W} and Groen, {Albert K} and {Human Functional Genomics Project} and Riksen, {Niels P} and Rutten, {Joost H W} and Joosten, {Leo A B} and Cisca Wijmenga and Alexandra Zhernakova and Netea, {Mihai G} and Jingyuan Fu and Folkert Kuipers",

year = "2020",

month = oct,

day = "6",

doi = "10.1016/j.celrep.2020.108212",

language = "English",

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Chen, L, Schraa, K, van den Munckhof, ICL, Ter Horst, R, Koehorst, M, van Faassen, M, van der Ley, C, Doestzada, M, Zhernakova, DV , Kurilshikov, A , Bloks, VW , Groen, AK, Human Functional Genomics Project, Riksen, NP, Rutten, JHW, Joosten, LAB, Wijmenga, C , Zhernakova, A, Netea, MG, Fu, J & Kuipers, F 2020, 'Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content', Cell reports, vol. 33, no. 1, 108212. https://doi.org/10.1016/j.celrep.2020.108212

Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content. / Chen, Lianmin; Schraa, Kiki; van den Munckhof, Inge C L; Ter Horst, Rob; Koehorst, Martijn; van Faassen, Martijn; van der Ley, Claude; Doestzada, Marwah; Zhernakova, Daria V ; Kurilshikov, Alexander ; Bloks, Vincent W ; Groen, Albert K; Human Functional Genomics Project; Riksen, Niels P; Rutten, Joost H W; Joosten, Leo A B; Wijmenga, Cisca ; Zhernakova, Alexandra; Netea, Mihai G; Fu, Jingyuan ; Kuipers, Folkert.

In: Cell reports, Vol. 33, No. 1, 108212, 06.10.2020.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content

AU - Chen, Lianmin

AU - Schraa, Kiki

AU - van den Munckhof, Inge C L

AU - Ter Horst, Rob

AU - Koehorst, Martijn

AU - van Faassen, Martijn

AU - van der Ley, Claude

AU - Doestzada, Marwah

AU - Zhernakova, Daria V

AU - Kurilshikov, Alexander

AU - Bloks, Vincent W

AU - Groen, Albert K

AU - Human Functional Genomics Project

AU - Riksen, Niels P

AU - Rutten, Joost H W

AU - Joosten, Leo A B

AU - Wijmenga, Cisca

AU - Zhernakova, Alexandra

AU - Netea, Mihai G

AU - Fu, Jingyuan

AU - Kuipers, Folkert

PY - 2020/10/6

Y1 - 2020/10/6

N2 - Bile acids (BAs) have been implicated in obesity-related conditions such as NAFLD and hyperlipidemia. Different human BAs exert variable biological activities. Chen et al. define genetic and microbial associations to plasma and fecal BA concentrations and composition in persons with obesity and establish their relationships with liver fat and lipid phenotypes.

AB - Bile acids (BAs) have been implicated in obesity-related conditions such as NAFLD and hyperlipidemia. Different human BAs exert variable biological activities. Chen et al. define genetic and microbial associations to plasma and fecal BA concentrations and composition in persons with obesity and establish their relationships with liver fat and lipid phenotypes.

KW - HUMANS

KW - HYPERTRIGLYCERIDEMIA

KW - MICE

U2 - 10.1016/j.celrep.2020.108212

DO - 10.1016/j.celrep.2020.108212

M3 - Article

C2 - 33027657

VL - 33

JO - Cell reports

JF - Cell reports

SN - 2211-1247

IS - 1

M1 - 108212

ER -