Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content

Lianmin Chen, Kiki Schraa, Inge C L van den Munckhof, Rob Ter Horst, Martijn Koehorst, Martijn van Faassen, Claude van der Ley, Marwah Doestzada, Daria V Zhernakova, Alexander Kurilshikov, Vincent W Bloks, Albert K Groen, Human Functional Genomics Project, Niels P Riksen, Joost H W Rutten, Leo A B Joosten, Cisca Wijmenga, Alexandra Zhernakova, Mihai G Netea, Jingyuan FuFolkert Kuipers

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Abstract

Bile acids (BAs) have been implicated in obesity-related conditions such as NAFLD and hyperlipidemia. Different human BAs exert variable biological activities. Chen et al. define genetic and microbial associations to plasma and fecal BA concentrations and composition in persons with obesity and establish their relationships with liver fat and lipid phenotypes.

Original languageEnglish
Article number108212
Number of pages13
JournalCell reports
Volume33
Issue number1
DOIs
Publication statusPublished - 6-Oct-2020

Keywords

  • HUMANS
  • HYPERTRIGLYCERIDEMIA
  • MICE

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