Genetic-Code-Expansion Strategies for Vaccine Development

Jelle A. Fok, Clemens Mayer*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

3 Citations (Scopus)
87 Downloads (Pure)

Abstract

Abstract: By providing long-term protection against infectious diseases, vaccinations have significantly reduced death and morbidity worldwide. In the 21st century, (bio)technological advances have paved the way for developing prophylactic vaccines that are safer and more effective as well as enabling the use of vaccines as therapeutics to treat human diseases. Here, we provide a focused review of the utility of genetic code expansion as an emerging tool for the development of vaccines. Specifically, we discuss how the incorporation of immunogenic noncanonical amino acids can aid in eliciting immune responses against adverse self-proteins and highlight the potential of an expanded genetic code for the construction of replication-incompetent viruses. We close the review by discussing the future prospects and remaining challenges for the application of these approaches in the development of both prophylactic and therapeutic vaccines in the near future.

Original languageEnglish
Pages (from-to)3291-3300
Number of pages10
JournalChemBioChem
Volume21
Issue number23
Early online date30-Jul-2020
DOIs
Publication statusPublished - 1-Dec-2020

Keywords

  • genetic code expansion
  • immunochemistry
  • protein modifications
  • vaccine development
  • virus attenuation
  • INFLUENZA-A VIRUSES
  • SELF-TOLERANCE
  • IMMUNE-DEFICIENCY
  • IMMUNOCHEMICAL TERMINATION
  • HIV-1 VACCINE
  • AMINO-ACIDS
  • LIVE
  • DESIGN
  • REPLICATION
  • MECHANISMS

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