Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases

Olga Alvarenga Fernandes Sin; Helen Michels; Ellen A. A. Nollen

doi:10.1016/j.bbadis.2014.01.015

Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases

Olga Alvarenga Fernandes Sin, Helen Michels, Ellen A. A. Nollen^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

50 Citations (Scopus)

Abstract

Caenorhabditis elegans comprises unique features that make it an attractive model organism in diverse fields of biology. Genetic screens are powerful to identify genes and C. elegans can be customized to forward or reverse genetic screens and to establish gene function. These genetic screens can be applied to "humanized" models of C. elegans for neurodegenerative diseases, enabling for example the identification of genes involved in protein aggregation, one of the hallmarks of these diseases. In this review, we will describe the genetic screens employed in C. elegans and how these can be used to understand molecular processes involved in neurodegenerative and other human diseases. This article is part of a Special Issue entitled: From Genome to Function. (C) 2014 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	1951-1959
Number of pages	9
Journal	Biochimica et biophysica acta-Molecular basis of disease
Volume	1842
Issue number	10
DOIs	https://doi.org/10.1016/j.bbadis.2014.01.015
Publication status	Published - Oct-2014

Keywords

Caenorhabditis elegans
Nematode
Genetic screen
RNAi
EMS
Neurodegenerative disease
Modifier gene
SYSTEMATIC RNAI SCREEN
BETA-AMYLOID PEPTIDE
PARKINSONS-DISEASE
ALPHA-SYNUCLEIN
ALZHEIMERS-DISEASE
C-ELEGANS
BODY FORMATION
CELL-DEATH
LIFE-SPAN
PROTEIN

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title = "Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases",

abstract = "Caenorhabditis elegans comprises unique features that make it an attractive model organism in diverse fields of biology. Genetic screens are powerful to identify genes and C. elegans can be customized to forward or reverse genetic screens and to establish gene function. These genetic screens can be applied to {"}humanized{"} models of C. elegans for neurodegenerative diseases, enabling for example the identification of genes involved in protein aggregation, one of the hallmarks of these diseases. In this review, we will describe the genetic screens employed in C. elegans and how these can be used to understand molecular processes involved in neurodegenerative and other human diseases. This article is part of a Special Issue entitled: From Genome to Function. (C) 2014 Elsevier B.V. All rights reserved.",

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author = "{Alvarenga Fernandes Sin}, Olga and Helen Michels and Nollen, {Ellen A. A.}",

year = "2014",

month = oct,

doi = "10.1016/j.bbadis.2014.01.015",

language = "English",

volume = "1842",

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journal = "Biochimica et biophysica acta-Molecular basis of disease",

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T1 - Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases

AU - Alvarenga Fernandes Sin, Olga

AU - Michels, Helen

AU - Nollen, Ellen A. A.

PY - 2014/10

Y1 - 2014/10

N2 - Caenorhabditis elegans comprises unique features that make it an attractive model organism in diverse fields of biology. Genetic screens are powerful to identify genes and C. elegans can be customized to forward or reverse genetic screens and to establish gene function. These genetic screens can be applied to "humanized" models of C. elegans for neurodegenerative diseases, enabling for example the identification of genes involved in protein aggregation, one of the hallmarks of these diseases. In this review, we will describe the genetic screens employed in C. elegans and how these can be used to understand molecular processes involved in neurodegenerative and other human diseases. This article is part of a Special Issue entitled: From Genome to Function. (C) 2014 Elsevier B.V. All rights reserved.

AB - Caenorhabditis elegans comprises unique features that make it an attractive model organism in diverse fields of biology. Genetic screens are powerful to identify genes and C. elegans can be customized to forward or reverse genetic screens and to establish gene function. These genetic screens can be applied to "humanized" models of C. elegans for neurodegenerative diseases, enabling for example the identification of genes involved in protein aggregation, one of the hallmarks of these diseases. In this review, we will describe the genetic screens employed in C. elegans and how these can be used to understand molecular processes involved in neurodegenerative and other human diseases. This article is part of a Special Issue entitled: From Genome to Function. (C) 2014 Elsevier B.V. All rights reserved.

KW - Caenorhabditis elegans

KW - Nematode

KW - Genetic screen

KW - RNAi

KW - EMS

KW - Neurodegenerative disease

KW - Modifier gene

KW - SYSTEMATIC RNAI SCREEN

KW - BETA-AMYLOID PEPTIDE

KW - PARKINSONS-DISEASE

KW - ALPHA-SYNUCLEIN

KW - ALZHEIMERS-DISEASE

KW - C-ELEGANS

KW - BODY FORMATION

KW - CELL-DEATH

KW - LIFE-SPAN

KW - PROTEIN

U2 - 10.1016/j.bbadis.2014.01.015

DO - 10.1016/j.bbadis.2014.01.015

M3 - Review article

SN - 0925-4439

VL - 1842

SP - 1951

EP - 1959

JO - Biochimica et biophysica acta-Molecular basis of disease

JF - Biochimica et biophysica acta-Molecular basis of disease

IS - 10

ER -

Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases

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Keywords

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