Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

Michael A. van Es; Paul Wj van Vught; Hylke M. Blauw; Lude Franke; Christiaan G. J. Saris; Ludo Van Den Bosch; Sonja W. de Jong; Vianney de Jong; Frank Baas; Ruben van't Slot; Robin Lemmens; Helenius J. Schelhaas; Anna Birve; Kristel Sleegers; Christine Van Broeckhoven; Jennifer C. Schymick; Bryan J. Traynor; John H. J. Wokke; Cisca Wijmenga; Wim Robberecht; Peter M. Andersen; Jan H. Veldink; Roel A. Ophoff; Leonard H. van den Berg

doi:10.1038/ng.2007.52

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

Michael A. van Es
, Paul Wj van Vught
, Hylke M. Blauw
, Lude Franke
, Christiaan G. J. Saris
, Ludo Van Den Bosch
, Sonja W. de Jong
, Vianney de Jong
, Frank Baas
, Ruben van't Slot
, Robin Lemmens
, Helenius J. Schelhaas
, Anna Birve
, Kristel Sleegers
, Christine Van Broeckhoven
, Jennifer C. Schymick
, Bryan J. Traynor
, John H. J. Wokke
, Cisca Wijmenga
, Wim Robberecht

Peter M. Andersen, Jan H. Veldink, Roel A. Ophoff, Leonard H. van den Berg^*

^*Corresponding author for this work

Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)

Research output: Contribution to journal › Article › Academic › peer-review

199 Citations (Scopus)

Abstract

We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04x10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18 - 1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.

Original language	English
Pages (from-to)	29-31
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	1
DOIs	https://doi.org/10.1038/ng.2007.52
Publication status	Published - Jan-2008

Keywords

SPORADIC ALS
MUTATIONS

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van Es, M. A., van Vught, P. W., Blauw, H. M., Franke, L., Saris, C. G. J., Van Den Bosch, L., de Jong, S. W., de Jong, V., Baas, F., van't Slot, R., Lemmens, R., Schelhaas, H. J., Birve, A., Sleegers, K., Van Broeckhoven, C., Schymick, J. C., Traynor, B. J., Wokke, J. H. J., Wijmenga, C., ... van den Berg, L. H. (2008). Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. Nature Genetics, 40(1), 29-31. https://doi.org/10.1038/ng.2007.52

@article{b5e160610f6246c889490b307c09cb69,

title = "Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis",

abstract = "We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04x10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95\% confidence interval (CI) of 1.18 - 1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.",

keywords = "SPORADIC ALS, MUTATIONS",

author = "\{van Es\}, \{Michael A.\} and \{van Vught\}, \{Paul Wj\} and Blauw, \{Hylke M.\} and Lude Franke and Saris, \{Christiaan G. J.\} and \{Van Den Bosch\}, Ludo and \{de Jong\}, \{Sonja W.\} and \{de Jong\}, Vianney and Frank Baas and \{van't Slot\}, Ruben and Robin Lemmens and Schelhaas, \{Helenius J.\} and Anna Birve and Kristel Sleegers and \{Van Broeckhoven\}, Christine and Schymick, \{Jennifer C.\} and Traynor, \{Bryan J.\} and Wokke, \{John H. J.\} and Cisca Wijmenga and Wim Robberecht and Andersen, \{Peter M.\} and Veldink, \{Jan H.\} and Ophoff, \{Roel A.\} and \{van den Berg\}, \{Leonard H.\}",

year = "2008",

month = jan,

doi = "10.1038/ng.2007.52",

language = "English",

volume = "40",

pages = "29--31",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "1",

}

van Es, MA, van Vught, PW, Blauw, HM, Franke, L, Saris, CGJ, Van Den Bosch, L, de Jong, SW, de Jong, V, Baas, F, van't Slot, R, Lemmens, R, Schelhaas, HJ, Birve, A, Sleegers, K, Van Broeckhoven, C, Schymick, JC, Traynor, BJ, Wokke, JHJ, Wijmenga, C, Robberecht, W, Andersen, PM, Veldink, JH, Ophoff, RA & van den Berg, LH 2008, 'Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis', Nature Genetics, vol. 40, no. 1, pp. 29-31. https://doi.org/10.1038/ng.2007.52

TY - JOUR

T1 - Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

AU - van Es, Michael A.

AU - van Vught, Paul Wj

AU - Blauw, Hylke M.

AU - Franke, Lude

AU - Saris, Christiaan G. J.

AU - Van Den Bosch, Ludo

AU - de Jong, Sonja W.

AU - de Jong, Vianney

AU - Baas, Frank

AU - van't Slot, Ruben

AU - Lemmens, Robin

AU - Schelhaas, Helenius J.

AU - Birve, Anna

AU - Sleegers, Kristel

AU - Van Broeckhoven, Christine

AU - Schymick, Jennifer C.

AU - Traynor, Bryan J.

AU - Wokke, John H. J.

AU - Wijmenga, Cisca

AU - Robberecht, Wim

AU - Andersen, Peter M.

AU - Veldink, Jan H.

AU - Ophoff, Roel A.

AU - van den Berg, Leonard H.

PY - 2008/1

Y1 - 2008/1

N2 - We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04x10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18 - 1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.

AB - We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04x10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18 - 1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.

KW - SPORADIC ALS

KW - MUTATIONS

U2 - 10.1038/ng.2007.52

DO - 10.1038/ng.2007.52

M3 - Article

SN - 1061-4036

VL - 40

SP - 29

EP - 31

JO - Nature Genetics

JF - Nature Genetics

IS - 1

ER -

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

Abstract

Keywords

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