Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

Daniele Campa; James McKay; Olga Sinilnikova; Anika Hüsing; Ulla Vogel; Rikke Dalgaard Hansen; Kim Overvad; Petra Mariann Witt; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Veronique Chajes; Sabine Rohrmann; Jenny Chang-Claude; Heiner Boeing; Eva Fisher; Antonia Trichopoulou; Dimitrios Trichopoulos; Domenico Palli; Anna Villarini; Carlotta Sacerdote; Amalia Mattiello; Rosario Tumino; Petra H M Peeters; Carla H van Gils; H Bas Bueno-de-Mesquita; Eiliv Lund; María Dolores Chirlaque; Núria Sala; Laudina Rodriguez Suarez; Aurelio Barricarte; Miren Dorronsoro; Maria-José Sánchez; Per Lenner; Göran Hallmans; Kostas Tsilidis; Sheila Bingham; Kay-Tee Khaw; Valentina Gallo; Teresa Norat; Elio Riboli; Sabina Rinaldi; Gilbert Lenoir; Sean V Tavtigian; Federico Canzian; Rudolf Kaaks

doi:10.1007/s10549-009-0347-8

Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

Daniele Campa, James McKay, Olga Sinilnikova, Anika Hüsing, Ulla Vogel, Rikke Dalgaard Hansen, Kim Overvad, Petra Mariann Witt, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Veronique Chajes, Sabine Rohrmann, Jenny Chang-Claude, Heiner Boeing, Eva Fisher, Antonia Trichopoulou, Dimitrios Trichopoulos, Domenico Palli, Anna Villarini, Carlotta SacerdoteAmalia Mattiello, Rosario Tumino, Petra H M Peeters, Carla H van Gils, H Bas Bueno-de-Mesquita, Eiliv Lund, María Dolores Chirlaque, Núria Sala, Laudina Rodriguez Suarez, Aurelio Barricarte, Miren Dorronsoro, Maria-José Sánchez, Per Lenner, Göran Hallmans, Kostas Tsilidis, Sheila Bingham, Kay-Tee Khaw, Valentina Gallo, Teresa Norat, Elio Riboli, Sabina Rinaldi, Gilbert Lenoir, Sean V Tavtigian, Federico Canzian, Rudolf Kaaks

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

Abstract

Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL, SREBF1 and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). We resequenced the FAS gene and combined information of SNPs found by resequencing and SNPs from public databases. Using a tagging approach and selecting 20 SNPs, we covered all the common genetic variation of these genes. In this study we were not able to find any statistically significant association between the SNPs in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer overall and by subgroups of age, menopausal status, hormone replacement therapy (HRT) use or BMI. On the other hand, we found that two SNPs in FASN were associated with BMI.

Original language	English
Pages (from-to)	565-574
Number of pages	10
Journal	Breast Cancer Research and Treatment
Volume	118
Issue number	3
DOIs	https://doi.org/10.1007/s10549-009-0347-8
Publication status	Published - Dec-2009
Externally published	Yes

Keywords

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics
Body Mass Index
Breast Neoplasms/genetics
Fatty Acid Synthase, Type I/genetics
Female
Genetic Predisposition to Disease
Genetic Variation
Humans
Obesity/genetics
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Risk Factors
Sterol Regulatory Element Binding Protein 1/genetics

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Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk
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Campa, D., McKay, J., Sinilnikova, O., Hüsing, A., Vogel, U., Hansen, R. D., Overvad, K., Witt, P. M., Clavel-Chapelon, F., Boutron-Ruault, M-C., Chajes, V., Rohrmann, S., Chang-Claude, J., Boeing, H., Fisher, E., Trichopoulou, A., Trichopoulos, D., Palli, D., Villarini, A., ... Kaaks, R. (2009). Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk. Breast Cancer Research and Treatment, 118(3), 565-574. https://doi.org/10.1007/s10549-009-0347-8

Campa, Daniele ; McKay, James ; Sinilnikova, Olga ; Hüsing, Anika ; Vogel, Ulla ; Hansen, Rikke Dalgaard ; Overvad, Kim ; Witt, Petra Mariann ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie-Christine ; Chajes, Veronique ; Rohrmann, Sabine ; Chang-Claude, Jenny ; Boeing, Heiner ; Fisher, Eva ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Palli, Domenico ; Villarini, Anna ; Sacerdote, Carlotta ; Mattiello, Amalia ; Tumino, Rosario ; Peeters, Petra H M ; van Gils, Carla H ; Bas Bueno-de-Mesquita, H ; Lund, Eiliv ; Chirlaque, María Dolores ; Sala, Núria ; Suarez, Laudina Rodriguez ; Barricarte, Aurelio ; Dorronsoro, Miren ; Sánchez, Maria-José ; Lenner, Per ; Hallmans, Göran ; Tsilidis, Kostas ; Bingham, Sheila ; Khaw, Kay-Tee ; Gallo, Valentina ; Norat, Teresa ; Riboli, Elio ; Rinaldi, Sabina ; Lenoir, Gilbert ; Tavtigian, Sean V ; Canzian, Federico ; Kaaks, Rudolf. / Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk. In: Breast Cancer Research and Treatment. 2009 ; Vol. 118, No. 3. pp. 565-574.

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title = "Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk",

abstract = "Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL, SREBF1 and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). We resequenced the FAS gene and combined information of SNPs found by resequencing and SNPs from public databases. Using a tagging approach and selecting 20 SNPs, we covered all the common genetic variation of these genes. In this study we were not able to find any statistically significant association between the SNPs in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer overall and by subgroups of age, menopausal status, hormone replacement therapy (HRT) use or BMI. On the other hand, we found that two SNPs in FASN were associated with BMI.",

keywords = "Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics, Body Mass Index, Breast Neoplasms/genetics, Fatty Acid Synthase, Type I/genetics, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Obesity/genetics, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Risk Factors, Sterol Regulatory Element Binding Protein 1/genetics",

author = "Daniele Campa and James McKay and Olga Sinilnikova and Anika H{\"u}sing and Ulla Vogel and Hansen, {Rikke Dalgaard} and Kim Overvad and Witt, {Petra Mariann} and Fran{\c c}oise Clavel-Chapelon and Marie-Christine Boutron-Ruault and Veronique Chajes and Sabine Rohrmann and Jenny Chang-Claude and Heiner Boeing and Eva Fisher and Antonia Trichopoulou and Dimitrios Trichopoulos and Domenico Palli and Anna Villarini and Carlotta Sacerdote and Amalia Mattiello and Rosario Tumino and Peeters, {Petra H M} and {van Gils}, {Carla H} and {Bas Bueno-de-Mesquita}, H and Eiliv Lund and Chirlaque, {Mar{\'i}a Dolores} and N{\'u}ria Sala and Suarez, {Laudina Rodriguez} and Aurelio Barricarte and Miren Dorronsoro and Maria-Jos{\'e} S{\'a}nchez and Per Lenner and G{\"o}ran Hallmans and Kostas Tsilidis and Sheila Bingham and Kay-Tee Khaw and Valentina Gallo and Teresa Norat and Elio Riboli and Sabina Rinaldi and Gilbert Lenoir and Tavtigian, {Sean V} and Federico Canzian and Rudolf Kaaks",

year = "2009",

month = dec,

doi = "10.1007/s10549-009-0347-8",

language = "English",

volume = "118",

pages = "565--574",

journal = "Breast Cancer Research and Treatment",

issn = "0167-6806",

publisher = "SPRINGER",

number = "3",

}

Campa, D, McKay, J, Sinilnikova, O, Hüsing, A, Vogel, U, Hansen, RD, Overvad, K, Witt, PM, Clavel-Chapelon, F, Boutron-Ruault, M-C, Chajes, V, Rohrmann, S, Chang-Claude, J, Boeing, H, Fisher, E, Trichopoulou, A, Trichopoulos, D, Palli, D, Villarini, A, Sacerdote, C, Mattiello, A, Tumino, R, Peeters, PHM, van Gils, CH, Bas Bueno-de-Mesquita, H, Lund, E, Chirlaque, MD, Sala, N, Suarez, LR, Barricarte, A, Dorronsoro, M, Sánchez, M-J, Lenner, P, Hallmans, G, Tsilidis, K, Bingham, S, Khaw, K-T, Gallo, V, Norat, T, Riboli, E, Rinaldi, S, Lenoir, G, Tavtigian, SV, Canzian, F & Kaaks, R 2009, 'Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk', Breast Cancer Research and Treatment, vol. 118, no. 3, pp. 565-574. https://doi.org/10.1007/s10549-009-0347-8

Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk. / Campa, Daniele; McKay, James; Sinilnikova, Olga; Hüsing, Anika; Vogel, Ulla; Hansen, Rikke Dalgaard; Overvad, Kim; Witt, Petra Mariann; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie-Christine; Chajes, Veronique; Rohrmann, Sabine; Chang-Claude, Jenny; Boeing, Heiner; Fisher, Eva; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Palli, Domenico; Villarini, Anna; Sacerdote, Carlotta; Mattiello, Amalia; Tumino, Rosario; Peeters, Petra H M; van Gils, Carla H; Bas Bueno-de-Mesquita, H; Lund, Eiliv; Chirlaque, María Dolores; Sala, Núria; Suarez, Laudina Rodriguez; Barricarte, Aurelio; Dorronsoro, Miren; Sánchez, Maria-José; Lenner, Per; Hallmans, Göran; Tsilidis, Kostas; Bingham, Sheila; Khaw, Kay-Tee; Gallo, Valentina; Norat, Teresa; Riboli, Elio; Rinaldi, Sabina; Lenoir, Gilbert; Tavtigian, Sean V; Canzian, Federico; Kaaks, Rudolf.

In: Breast Cancer Research and Treatment, Vol. 118, No. 3, 12.2009, p. 565-574.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

AU - Campa, Daniele

AU - McKay, James

AU - Sinilnikova, Olga

AU - Hüsing, Anika

AU - Vogel, Ulla

AU - Hansen, Rikke Dalgaard

AU - Overvad, Kim

AU - Witt, Petra Mariann

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie-Christine

AU - Chajes, Veronique

AU - Rohrmann, Sabine

AU - Chang-Claude, Jenny

AU - Boeing, Heiner

AU - Fisher, Eva

AU - Trichopoulou, Antonia

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Villarini, Anna

AU - Sacerdote, Carlotta

AU - Mattiello, Amalia

AU - Tumino, Rosario

AU - Peeters, Petra H M

AU - van Gils, Carla H

AU - Bas Bueno-de-Mesquita, H

AU - Lund, Eiliv

AU - Chirlaque, María Dolores

AU - Sala, Núria

AU - Suarez, Laudina Rodriguez

AU - Barricarte, Aurelio

AU - Dorronsoro, Miren

AU - Sánchez, Maria-José

AU - Lenner, Per

AU - Hallmans, Göran

AU - Tsilidis, Kostas

AU - Bingham, Sheila

AU - Khaw, Kay-Tee

AU - Gallo, Valentina

AU - Norat, Teresa

AU - Riboli, Elio

AU - Rinaldi, Sabina

AU - Lenoir, Gilbert

AU - Tavtigian, Sean V

AU - Canzian, Federico

AU - Kaaks, Rudolf

PY - 2009/12

Y1 - 2009/12

N2 - Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL, SREBF1 and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). We resequenced the FAS gene and combined information of SNPs found by resequencing and SNPs from public databases. Using a tagging approach and selecting 20 SNPs, we covered all the common genetic variation of these genes. In this study we were not able to find any statistically significant association between the SNPs in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer overall and by subgroups of age, menopausal status, hormone replacement therapy (HRT) use or BMI. On the other hand, we found that two SNPs in FASN were associated with BMI.

AB - Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL, SREBF1 and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). We resequenced the FAS gene and combined information of SNPs found by resequencing and SNPs from public databases. Using a tagging approach and selecting 20 SNPs, we covered all the common genetic variation of these genes. In this study we were not able to find any statistically significant association between the SNPs in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer overall and by subgroups of age, menopausal status, hormone replacement therapy (HRT) use or BMI. On the other hand, we found that two SNPs in FASN were associated with BMI.

KW - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics

KW - Body Mass Index

KW - Breast Neoplasms/genetics

KW - Fatty Acid Synthase, Type I/genetics

KW - Female

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Humans

KW - Obesity/genetics

KW - Polymerase Chain Reaction

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

KW - Sterol Regulatory Element Binding Protein 1/genetics

U2 - 10.1007/s10549-009-0347-8

DO - 10.1007/s10549-009-0347-8

M3 - Article

C2 - 19252981

VL - 118

SP - 565

EP - 574

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 3

ER -