Genetics of Atrial Fibrillation in 2020 GWAS, Genome Sequencing, Polygenic Risk, and Beyond

Carolina Roselli, Michiel Rienstra, Patrick T. Ellinor*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Abstract

Atrial fibrillation is a common heart rhythm disorder that leads to an increased risk for stroke and heart failure. Atrial fibrillation is a complex disease with both environmental and genetic risk factors that contribute to the arrhythmia. Over the last decade, rapid progress has been made in identifying the genetic basis for this common condition. In this review, we provide an overview of the primary types of genetic analyses performed for atrial fibrillation, including linkage studies, genome-wide association studies, and studies of rare coding variation. With these results in mind, we aim to highlighting the existing knowledge gaps and future directions for atrial fibrillation genetics research.

Original languageEnglish
Pages (from-to)21-33
Number of pages13
JournalCirculation research
Volume127
Issue number1
DOIs
Publication statusPublished - 19-Jun-2020

Keywords

  • atrial fibrillation
  • exome
  • genetics
  • genome-wide association study
  • mutation
  • LOSS-OF-FUNCTION
  • FAMILIAL AGGREGATION
  • WIDE ASSOCIATION
  • COMMON VARIANTS
  • HIGH-THROUGHPUT
  • MUTATION
  • LOCI
  • SUSCEPTIBILITY
  • IDENTIFICATION
  • CHINESE

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