Genetics of different asthma phenotypes

Maartje Nieuwenhuis

    Research output: ThesisThesis fully internal (DIV)

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    Abstract

    The underlying mechanisms of asthma are only partly understood. Asthma is a complex disease with several different phenotypes. The question is if these phenotypes are all part of one disease or if they are separate disease entities. We aimed to unravel the genetic contribution to different phenotypes of asthma, such as the severity of hyperresponsiveness (increased susceptibility to inhaled substances with airway constriction as a result) and the response of hyperresponsiveness to inhaled corticosteroids as well as remission of asthma. We identified several new genes that are associated to these phenotypes of asthma, but also to the development of asthma. Furthermore, childhood predictors for asthma remission later in adulthood were investigated and identified.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Postma, Dirkje S., Supervisor
    • Koppelman, Gerard, Supervisor
    • Vonk, Judith, Co-supervisor
    Award date15-May-2017
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-90-367-9734-4
    Electronic ISBNs978-90-367-9733-7
    Publication statusPublished - 2017

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