GENETISCHE ASPECTEN BIJ HET METABOLISME VAN GENEESMIDDELEN: DE INTERINDIVIDUELE VERSCHILLEN VERDER ONTRAFELD

Translated title of the contribution: Interindividual differences disentangled. Genetic aspects of drug metabolism

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

For many enzymes involved in drug metabolism different phenotypes have been discovered with a wide range of enzymatic activity. In this way, oxidation (by cytochrome P450), N-acetylation (by N-acetyltransferase), glucuronidation (by uridine glucuronosyl transferase), sulfation (by sulfotransferase) and thiopurine S-methylation (by thiopurine S-methyl transferase) have been studied extensively. This research has led to a better understanding of the metabolic processes in the human liver. Several polymorphisms and their clinical consequences are discussed.
Translated title of the contributionInterindividual differences disentangled. Genetic aspects of drug metabolism
Original languageDutch
Pages (from-to)1679-1684
Number of pages6
JournalPharmaceutisch Weekblad
Volume133
Issue number45
Publication statusPublished - 6-Nov-1998

Keywords

  • acyltransferase
  • aldehyde dehydrogenase
  • bilirubin
  • cytochrome P450
  • glucuronosyltransferase
  • isoniazid
  • procainamide
  • sulfonamide
  • sulfotransferase
  • xenobiotic agent
  • article
  • Crigler Najjar syndrome
  • drug metabolism
  • enzyme activity
  • genetic polymorphism
  • Gilbert disease
  • human
  • pharmacogenetics
  • phenotype

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