Abstract
For many enzymes involved in drug metabolism different phenotypes have been discovered with a wide range of enzymatic activity. In this way, oxidation (by cytochrome P450), N-acetylation (by N-acetyltransferase), glucuronidation (by uridine glucuronosyl transferase), sulfation (by sulfotransferase) and thiopurine S-methylation (by thiopurine S-methyl transferase) have been studied extensively. This research has led to a better understanding of the metabolic processes in the human liver. Several polymorphisms and their clinical consequences are discussed.
| Translated title of the contribution | Interindividual differences disentangled. Genetic aspects of drug metabolism |
|---|---|
| Original language | Dutch |
| Pages (from-to) | 1679-1684 |
| Number of pages | 6 |
| Journal | Pharmaceutisch Weekblad |
| Volume | 133 |
| Issue number | 45 |
| Publication status | Published - 6-Nov-1998 |
Keywords
- acyltransferase
- aldehyde dehydrogenase
- bilirubin
- cytochrome P450
- glucuronosyltransferase
- isoniazid
- procainamide
- sulfonamide
- sulfotransferase
- xenobiotic agent
- article
- Crigler Najjar syndrome
- drug metabolism
- enzyme activity
- genetic polymorphism
- Gilbert disease
- human
- pharmacogenetics
- phenotype