@article{712f6be4d63d4d93a8998c65e9e3603a,
title = "Genome-wide analysis identifies 12 loci influencing human reproductive behavior",
abstract = "The genetic architecture of human reproductive behavior age at first birth (AFB) and number of children ever born (NEB) has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.",
keywords = "POLYCYSTIC-OVARY-SYNDROME, GENE PRIORITIZATION, QUALITY-CONTROL, HUMAN-DISEASES, G1 PHASE, ASSOCIATION, FERTILITY, MOUSE, PROTEIN, AGE",
author = "Nicola Barban and Rick Jansen and {de Vlaming}, Ronald and Ahmad Vaez and Mandemakers, {Jornt J} and Tropf, {Felix C} and Xia Shen and Wilson, {James F} and Chasman, {Daniel I} and Nolte, {Ilja M} and Vinicius Tragante and {van der Laan}, {Sander W} and Perry, {John R B} and Augustine Kong and Ahluwalia, {Tarunveer S} and Eva Albrecht and Laura Yerges-Armstrong and Gil Atzmon and Kirsi Auro and Kristin Ayers and Andrew Bakshi and Danny Ben-Avraham and Klaus Berger and Aviv Bergman and Lars Bertram and Bielak, {Lawrence F} and Gyda Bjornsdottir and Bonder, {Marc Jan} and Linda Broer and Minh Bui and Caterina Barbieri and Alana Cavadino and Chavarro, {Jorge E} and Constance Turman and Concas, {Maria Pina} and Cordell, {Heather J} and Gail Davies and Peter Eibich and Nicholas Eriksson and Fahimeh Falahi and Lude Franke and Vasiliki Lagou and Meddens, {S Fleur W} and {van der Most}, {Peter J} and Zhao, {Jing Hua} and Zhernakova, {Daria V} and Penninx, {Brenda W J H} and Swertz, {Morris A} and Harold Snieder and Mills, {Melinda C} and {BIOS Consortium}",
year = "2016",
month = dec,
doi = "10.1038/ng.3698",
language = "English",
volume = "48",
pages = "1462--1472",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "12",
}