Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

eQTLgen Consortium, Iain Mathieson*, Felix R Day, Nicola Barban, Felix C Tropf, David M Brazel, Ahmad Vaez, Natalie van Zuydam, Bárbara D Bitarello, Eugene J Gardner, Evelina T Akimova, Ajuna Azad, Sven Bergmann, Lawrence F Bielak, Dorret I Boomsma, Kristina Bosak, Marco Brumat, Julie E Buring, David Cesarini, Daniel I ChasmanJorge E Chavarro, Massimiliano Cocca, Maria Pina Concas, George Davey Smith, Gail Davies, Ian J Deary, Tõnu Esko, Jessica D Faul, Oscar Franco, Andrea Ganna, Audrey J Gaskins, Andrea Gelemanovic, Eco J C de Geus, Christian Gieger, Giorgia Girotto, Bamini Gopinath, Hans Jörgen Grabe, Erica P Gunderson, Caroline Hayward, Chunyan He, Diana van Heemst, W David Hill, Zoha Kamali, Peter J van der Most, Ilja M Nolte, Brenda W J H Penninx, Morris A Swertz, Jing Hau Zhao, Wei Zhao, Harold Snieder, Melinda C Mills*, John R. B. Perry

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
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Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and identify alleles under present-day selection. Using data in 785,604 individuals of European ancestry, we identified 43 genomic loci associated with either number of children ever born (NEB) or childlessness. These loci span diverse aspects of reproductive biology, including puberty timing, age at first birth, sex hormone regulation, endometriosis and age at menopause. Missense variants in ARHGAP27 were associated with higher NEB but shorter reproductive lifespan, suggesting a trade-off at this locus between reproductive ageing and intensity. Other genes implicated by coding variants include PIK3IP1, ZFP82 and LRP4, and our results suggest a new role for the melanocortin 1 receptor (MC1R) in reproductive biology. As NEB is one component of evolutionary fitness, our identified associations indicate loci under present-day natural selection. Integration with data from historical selection scans highlighted an allele in the FADS1/2 gene locus that has been under selection for thousands of years and remains so today. Collectively, our findings demonstrate that a broad range of biological mechanisms contribute to reproductive success.

Original languageEnglish
Pages (from-to)790–801
Number of pages12
JournalNature Human Behaviour
Early online date2-Mar-2023
Publication statusPublished - May-2023


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