Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

Harmen H. M. Draisma; Rene Pool; Michael Kobl; Rick Jansen; Ann-Kristin Petersen; Anika A. M. Vaarhorst; Idil Yet; Toomas Haller; Ayse Demirkan; Tonu Esko; Gu Zhu; Stefan Boehringer; Marian Beekman; Jan Bert van Klinken; Werner Roemisch-Margl; Cornelia Prehn; Jerzy Adamski; Anton J. M. de Craen; Elisabeth M. van Leeuwen; Najaf Amin; Harish Dharuri; Harm-Jan Westra; Lude Franke; Eco J. C. de Geus; Jouke Jan Hottenga; Gonneke Willemsen; Anjali K. Henders; Grant W. Montgomery; Dale R. Nyholt; John B. Whitfield; Brenda W. Penninx; Tim D. Spector; Andres Metspalu; P. Eline Slagboom; Ko Willems van Dijk; Peter A. C. 't Hoen; Konstantin Strauch; Nicholas G. Martin; Gert-Jan B. van Ommen; Thomas Illig; Jordana T. Bell; Massimo Mangino; Karsten Suhre; Mark I. McCarthy; Christian Gieger; Aaron Isaacs; Cornelia M. van Duijn; Dorret I. Boomsma

doi:10.1038/ncomms8208

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

Harmen H. M. Draisma^*, Rene Pool, Michael Kobl, Rick Jansen, Ann-Kristin Petersen, Anika A. M. Vaarhorst, Idil Yet, Toomas Haller, Ayse Demirkan, Tonu Esko, Gu Zhu, Stefan Boehringer, Marian Beekman, Jan Bert van Klinken, Werner Roemisch-Margl, Cornelia Prehn, Jerzy Adamski, Anton J. M. de Craen, Elisabeth M. van Leeuwen, Najaf AminHarish Dharuri, Harm-Jan Westra, Lude Franke, Eco J. C. de Geus, Jouke Jan Hottenga, Gonneke Willemsen, Anjali K. Henders, Grant W. Montgomery, Dale R. Nyholt, John B. Whitfield, Brenda W. Penninx, Tim D. Spector, Andres Metspalu, P. Eline Slagboom, Ko Willems van Dijk, Peter A. C. 't Hoen, Konstantin Strauch, Nicholas G. Martin, Gert-Jan B. van Ommen, Thomas Illig, Jordana T. Bell, Massimo Mangino, Karsten Suhre, Mark I. McCarthy, Christian Gieger, Aaron Isaacs, Cornelia M. van Duijn, Dorret I. Boomsma

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates metabolomic platform. In a discovery sample of 7,478 individuals of European descent, we find 4,068 genome-and metabolome-wide significant (Z-test, P

Original language	English
Article number	7208
Number of pages	9
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms8208
Publication status	Published - Jun-2015

Keywords

CORONARY-ARTERY-DISEASE
ARGININE BIOAVAILABILITY
COMMON VARIANTS
LOCI
SERUM
METAANALYSIS
POPULATION
SOFTWARE
TRAITS
RISK

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Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levelsFinal publisher's version, 1.18 MBLicence: CC BY

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Draisma, H. H. M., Pool, R., Kobl, M., Jansen, R., Petersen, A-K., Vaarhorst, A. A. M., Yet, I., Haller, T., Demirkan, A., Esko, T., Zhu, G., Boehringer, S., Beekman, M., van Klinken, J. B., Roemisch-Margl, W., Prehn, C., Adamski, J., de Craen, A. J. M., van Leeuwen, E. M., ... Boomsma, D. I. (2015). Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. Nature Communications, 6, [7208]. https://doi.org/10.1038/ncomms8208

Draisma, Harmen H. M. ; Pool, Rene ; Kobl, Michael ; Jansen, Rick ; Petersen, Ann-Kristin ; Vaarhorst, Anika A. M. ; Yet, Idil ; Haller, Toomas ; Demirkan, Ayse ; Esko, Tonu ; Zhu, Gu ; Boehringer, Stefan ; Beekman, Marian ; van Klinken, Jan Bert ; Roemisch-Margl, Werner ; Prehn, Cornelia ; Adamski, Jerzy ; de Craen, Anton J. M. ; van Leeuwen, Elisabeth M. ; Amin, Najaf ; Dharuri, Harish ; Westra, Harm-Jan ; Franke, Lude ; de Geus, Eco J. C. ; Hottenga, Jouke Jan ; Willemsen, Gonneke ; Henders, Anjali K. ; Montgomery, Grant W. ; Nyholt, Dale R. ; Whitfield, John B. ; Penninx, Brenda W. ; Spector, Tim D. ; Metspalu, Andres ; Slagboom, P. Eline ; van Dijk, Ko Willems ; 't Hoen, Peter A. C. ; Strauch, Konstantin ; Martin, Nicholas G. ; van Ommen, Gert-Jan B. ; Illig, Thomas ; Bell, Jordana T. ; Mangino, Massimo ; Suhre, Karsten ; McCarthy, Mark I. ; Gieger, Christian ; Isaacs, Aaron ; van Duijn, Cornelia M. ; Boomsma, Dorret I. / Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. In: Nature Communications. 2015 ; Vol. 6.

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title = "Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels",

abstract = "Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates metabolomic platform. In a discovery sample of 7,478 individuals of European descent, we find 4,068 genome-and metabolome-wide significant (Z-test, P",

keywords = "CORONARY-ARTERY-DISEASE, ARGININE BIOAVAILABILITY, COMMON VARIANTS, LOCI, SERUM, METAANALYSIS, POPULATION, SOFTWARE, TRAITS, RISK",

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year = "2015",

month = jun,

doi = "10.1038/ncomms8208",

language = "English",

volume = "6",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

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Draisma, HHM, Pool, R, Kobl, M, Jansen, R, Petersen, A-K, Vaarhorst, AAM, Yet, I, Haller, T, Demirkan, A, Esko, T, Zhu, G, Boehringer, S, Beekman, M, van Klinken, JB, Roemisch-Margl, W, Prehn, C, Adamski, J, de Craen, AJM, van Leeuwen, EM, Amin, N, Dharuri, H, Westra, H-J , Franke, L, de Geus, EJC, Hottenga, JJ, Willemsen, G, Henders, AK, Montgomery, GW, Nyholt, DR, Whitfield, JB, Penninx, BW, Spector, TD, Metspalu, A, Slagboom, PE, van Dijk, KW, 't Hoen, PAC, Strauch, K, Martin, NG, van Ommen, G-JB, Illig, T, Bell, JT, Mangino, M, Suhre, K, McCarthy, MI, Gieger, C, Isaacs, A, van Duijn, CM & Boomsma, DI 2015, 'Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels', Nature Communications, vol. 6, 7208. https://doi.org/10.1038/ncomms8208

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. / Draisma, Harmen H. M.; Pool, Rene; Kobl, Michael; Jansen, Rick; Petersen, Ann-Kristin; Vaarhorst, Anika A. M.; Yet, Idil; Haller, Toomas; Demirkan, Ayse; Esko, Tonu; Zhu, Gu; Boehringer, Stefan; Beekman, Marian; van Klinken, Jan Bert; Roemisch-Margl, Werner; Prehn, Cornelia; Adamski, Jerzy; de Craen, Anton J. M.; van Leeuwen, Elisabeth M.; Amin, Najaf; Dharuri, Harish; Westra, Harm-Jan ; Franke, Lude; de Geus, Eco J. C.; Hottenga, Jouke Jan; Willemsen, Gonneke; Henders, Anjali K.; Montgomery, Grant W.; Nyholt, Dale R.; Whitfield, John B.; Penninx, Brenda W.; Spector, Tim D.; Metspalu, Andres; Slagboom, P. Eline; van Dijk, Ko Willems; 't Hoen, Peter A. C.; Strauch, Konstantin; Martin, Nicholas G.; van Ommen, Gert-Jan B.; Illig, Thomas; Bell, Jordana T.; Mangino, Massimo; Suhre, Karsten; McCarthy, Mark I.; Gieger, Christian; Isaacs, Aaron; van Duijn, Cornelia M.; Boomsma, Dorret I.

In: Nature Communications, Vol. 6, 7208, 06.2015.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

AU - Draisma, Harmen H. M.

AU - Pool, Rene

AU - Kobl, Michael

AU - Jansen, Rick

AU - Petersen, Ann-Kristin

AU - Vaarhorst, Anika A. M.

AU - Yet, Idil

AU - Haller, Toomas

AU - Demirkan, Ayse

AU - Esko, Tonu

AU - Zhu, Gu

AU - Boehringer, Stefan

AU - Beekman, Marian

AU - van Klinken, Jan Bert

AU - Roemisch-Margl, Werner

AU - Prehn, Cornelia

AU - Adamski, Jerzy

AU - de Craen, Anton J. M.

AU - van Leeuwen, Elisabeth M.

AU - Amin, Najaf

AU - Dharuri, Harish

AU - Westra, Harm-Jan

AU - Franke, Lude

AU - de Geus, Eco J. C.

AU - Hottenga, Jouke Jan

AU - Willemsen, Gonneke

AU - Henders, Anjali K.

AU - Montgomery, Grant W.

AU - Nyholt, Dale R.

AU - Whitfield, John B.

AU - Penninx, Brenda W.

AU - Spector, Tim D.

AU - Metspalu, Andres

AU - Slagboom, P. Eline

AU - van Dijk, Ko Willems

AU - 't Hoen, Peter A. C.

AU - Strauch, Konstantin

AU - Martin, Nicholas G.

AU - van Ommen, Gert-Jan B.

AU - Illig, Thomas

AU - Bell, Jordana T.

AU - Mangino, Massimo

AU - Suhre, Karsten

AU - McCarthy, Mark I.

AU - Gieger, Christian

AU - Isaacs, Aaron

AU - van Duijn, Cornelia M.

AU - Boomsma, Dorret I.

PY - 2015/6

Y1 - 2015/6

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AB - Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates metabolomic platform. In a discovery sample of 7,478 individuals of European descent, we find 4,068 genome-and metabolome-wide significant (Z-test, P

KW - CORONARY-ARTERY-DISEASE

KW - ARGININE BIOAVAILABILITY

KW - COMMON VARIANTS

KW - LOCI

KW - SERUM

KW - METAANALYSIS

KW - POPULATION

KW - SOFTWARE

KW - TRAITS

KW - RISK

U2 - 10.1038/ncomms8208

DO - 10.1038/ncomms8208

M3 - Article

C2 - 26068415

VL - 6

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 7208

ER -