Genomic epidemiology of 2015-2016 Zika virus outbreak in Cape Verde

Oumar Faye; Maria de Lourdes Monteiro; Bram Vrancken; Matthieu Prot; Sebastian Lequime; Maryam Diarra; Oumar Ndiaye; Tomas Valdez; Sandra Tavarez; Jessica Ramos; Silvânia da Veiga Leal; Cecilio Pires; Antonio Moreira; Maria Filomena Tavares; Linete Fernandes; Jorge Noel Barreto; Maria do Céu Teixeira; Maria da Luz de Lima Mendonça; Carolina Cardoso da Silva Leite Gomes; Mariano Salazar Castellon; Laurence Ma; Frédéric Lemoine; Fabiana Gámbaro-Roglia; Déborah Delaune; Gamou Fall; Ibrahima Socé Fall; Mamadou Diop; Anavaj Sakuntabhai; Cheikh Loucoubar; Philippe Lemey; Edward C Holmes; Ousmane Faye; Amadou Alpha Sall; Etienne Simon-Loriere

doi:10.3201/eid2606.190928

Genomic epidemiology of 2015-2016 Zika virus outbreak in Cape Verde

Oumar Faye, Maria de Lourdes Monteiro, Bram Vrancken, Matthieu Prot, Sebastian Lequime, Maryam Diarra, Oumar Ndiaye, Tomas Valdez, Sandra Tavarez, Jessica Ramos, Silvânia da Veiga Leal, Cecilio Pires, Antonio Moreira, Maria Filomena Tavares, Linete Fernandes, Jorge Noel Barreto, Maria do Céu Teixeira, Maria da Luz de Lima Mendonça, Carolina Cardoso da Silva Leite Gomes, Mariano Salazar CastellonLaurence Ma, Frédéric Lemoine, Fabiana Gámbaro-Roglia, Déborah Delaune, Gamou Fall, Ibrahima Socé Fall, Mamadou Diop, Anavaj Sakuntabhai, Cheikh Loucoubar, Philippe Lemey, Edward C Holmes, Ousmane Faye, Amadou Alpha Sall, Etienne Simon-Loriere^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

19 Citations (Scopus)

Abstract

During 2015-2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected Zika cases and 18 microcephaly cases. Analysis of the complete genomes of 3 ZIKV isolates from the outbreak indicated the strain was of the Asian (not African) lineage. The Cape Verde ZIKV sequences formed a distinct monophylogenetic group and possessed 1-2 (T659A, I756V) unique amino acid changes in the envelope protein. Phylogeographic and serologic evidence support earlier introduction of this lineage into Cape Verde, possibly from northeast Brazil, between June 2014 and August 2015, suggesting cryptic circulation of the virus before the initial wave of cases were detected in October 2015. These findings underscore the utility of genomic-scale epidemiology for outbreak investigations.

Original language	English
Pages (from-to)	1084-1090
Number of pages	7
Journal	Emerging Infectious Diseases
Volume	26
Issue number	6
DOIs	https://doi.org/10.3201/eid2606.190928
Publication status	Published - Jun-2020
Externally published	Yes

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Faye, O., de Lourdes Monteiro, M., Vrancken, B., Prot, M., Lequime, S., Diarra, M., Ndiaye, O., Valdez, T., Tavarez, S., Ramos, J., da Veiga Leal, S., Pires, C., Moreira, A., Tavares, M. F., Fernandes, L., Barreto, J. N., do Céu Teixeira, M., de Lima Mendonça, M. D. L., Gomes, C. C. D. S. L., ... Simon-Loriere, E. (2020). Genomic epidemiology of 2015-2016 Zika virus outbreak in Cape Verde. Emerging Infectious Diseases, 26(6), 1084-1090. https://doi.org/10.3201/eid2606.190928

@article{f08b038bc121417e81146e654125e764,

title = "Genomic epidemiology of 2015-2016 Zika virus outbreak in Cape Verde",

abstract = "During 2015-2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected Zika cases and 18 microcephaly cases. Analysis of the complete genomes of 3 ZIKV isolates from the outbreak indicated the strain was of the Asian (not African) lineage. The Cape Verde ZIKV sequences formed a distinct monophylogenetic group and possessed 1-2 (T659A, I756V) unique amino acid changes in the envelope protein. Phylogeographic and serologic evidence support earlier introduction of this lineage into Cape Verde, possibly from northeast Brazil, between June 2014 and August 2015, suggesting cryptic circulation of the virus before the initial wave of cases were detected in October 2015. These findings underscore the utility of genomic-scale epidemiology for outbreak investigations.",

author = "Oumar Faye and {de Lourdes Monteiro}, Maria and Bram Vrancken and Matthieu Prot and Sebastian Lequime and Maryam Diarra and Oumar Ndiaye and Tomas Valdez and Sandra Tavarez and Jessica Ramos and {da Veiga Leal}, Silv{\^a}nia and Cecilio Pires and Antonio Moreira and Tavares, {Maria Filomena} and Linete Fernandes and Barreto, {Jorge Noel} and {do C{\'e}u Teixeira}, Maria and {de Lima Mendon{\c c}a}, {Maria da Luz} and Gomes, {Carolina Cardoso da Silva Leite} and Castellon, {Mariano Salazar} and Laurence Ma and Fr{\'e}d{\'e}ric Lemoine and Fabiana G{\'a}mbaro-Roglia and D{\'e}borah Delaune and Gamou Fall and Fall, {Ibrahima Soc{\'e}} and Mamadou Diop and Anavaj Sakuntabhai and Cheikh Loucoubar and Philippe Lemey and Holmes, {Edward C} and Ousmane Faye and Sall, {Amadou Alpha} and Etienne Simon-Loriere",

year = "2020",

month = jun,

doi = "10.3201/eid2606.190928",

language = "English",

volume = "26",

pages = "1084--1090",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "CENTERS DISEASE CONTROL & PREVENTION",

number = "6",

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Faye, O, de Lourdes Monteiro, M, Vrancken, B, Prot, M, Lequime, S, Diarra, M, Ndiaye, O, Valdez, T, Tavarez, S, Ramos, J, da Veiga Leal, S, Pires, C, Moreira, A, Tavares, MF, Fernandes, L, Barreto, JN, do Céu Teixeira, M, de Lima Mendonça, MDL, Gomes, CCDSL, Castellon, MS, Ma, L, Lemoine, F, Gámbaro-Roglia, F, Delaune, D, Fall, G, Fall, IS, Diop, M, Sakuntabhai, A, Loucoubar, C, Lemey, P, Holmes, EC, Faye, O, Sall, AA & Simon-Loriere, E 2020, 'Genomic epidemiology of 2015-2016 Zika virus outbreak in Cape Verde', Emerging Infectious Diseases, vol. 26, no. 6, pp. 1084-1090. https://doi.org/10.3201/eid2606.190928

TY - JOUR

T1 - Genomic epidemiology of 2015-2016 Zika virus outbreak in Cape Verde

AU - Faye, Oumar

AU - de Lourdes Monteiro, Maria

AU - Vrancken, Bram

AU - Prot, Matthieu

AU - Lequime, Sebastian

AU - Diarra, Maryam

AU - Ndiaye, Oumar

AU - Valdez, Tomas

AU - Tavarez, Sandra

AU - Ramos, Jessica

AU - da Veiga Leal, Silvânia

AU - Pires, Cecilio

AU - Moreira, Antonio

AU - Tavares, Maria Filomena

AU - Fernandes, Linete

AU - Barreto, Jorge Noel

AU - do Céu Teixeira, Maria

AU - de Lima Mendonça, Maria da Luz

AU - Gomes, Carolina Cardoso da Silva Leite

AU - Castellon, Mariano Salazar

AU - Ma, Laurence

AU - Lemoine, Frédéric

AU - Gámbaro-Roglia, Fabiana

AU - Delaune, Déborah

AU - Fall, Gamou

AU - Fall, Ibrahima Socé

AU - Diop, Mamadou

AU - Sakuntabhai, Anavaj

AU - Loucoubar, Cheikh

AU - Lemey, Philippe

AU - Holmes, Edward C

AU - Faye, Ousmane

AU - Sall, Amadou Alpha

AU - Simon-Loriere, Etienne

PY - 2020/6

Y1 - 2020/6

N2 - During 2015-2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected Zika cases and 18 microcephaly cases. Analysis of the complete genomes of 3 ZIKV isolates from the outbreak indicated the strain was of the Asian (not African) lineage. The Cape Verde ZIKV sequences formed a distinct monophylogenetic group and possessed 1-2 (T659A, I756V) unique amino acid changes in the envelope protein. Phylogeographic and serologic evidence support earlier introduction of this lineage into Cape Verde, possibly from northeast Brazil, between June 2014 and August 2015, suggesting cryptic circulation of the virus before the initial wave of cases were detected in October 2015. These findings underscore the utility of genomic-scale epidemiology for outbreak investigations.

AB - During 2015-2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected Zika cases and 18 microcephaly cases. Analysis of the complete genomes of 3 ZIKV isolates from the outbreak indicated the strain was of the Asian (not African) lineage. The Cape Verde ZIKV sequences formed a distinct monophylogenetic group and possessed 1-2 (T659A, I756V) unique amino acid changes in the envelope protein. Phylogeographic and serologic evidence support earlier introduction of this lineage into Cape Verde, possibly from northeast Brazil, between June 2014 and August 2015, suggesting cryptic circulation of the virus before the initial wave of cases were detected in October 2015. These findings underscore the utility of genomic-scale epidemiology for outbreak investigations.

U2 - 10.3201/eid2606.190928

DO - 10.3201/eid2606.190928

M3 - Article

C2 - 32441631

SN - 1080-6040

VL - 26

SP - 1084

EP - 1090

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 6

ER -