Germinal Centers in Diagnostic Biopsies of Patients With Primary Sjogren's Syndrome Are Not a Risk Factor for Non-Hodgkin's Lymphoma but a Reflection of High Disease Activity: Comment on the Article by Sene et al

Erlin A. Haacke*, Bert van der Vegt, Arjan Vissink, Fred K. L. Spijkervet, Hendrika Bootsma, Frans G. M. Kroese

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

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With great interest we have read the article of Sène et al. (1) in which ectopic germinal centres (GCs) in labial gland biopsies of primary Sjögren syndrome (pSS) patients were found predictive for Non-Hodgkin's lymphoma (NHL) development later in the disease. In the univariate analysis the presence of GCs in these biopsies was not significantly different between pSS patients that developed NHL or pSS patients that did not. This article is protected by copyright. All rights reserved.

Original languageEnglish
Pages (from-to)170-171
Number of pages2
JournalArthritis & Rheumatology
Issue number1
Early online date3-Sep-2018
Publication statusPublished - Jan-2019



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