Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue

Remko S. Kuipers*, Martine F. Luxwolda, Pieter J. Offringa, Ingrid A. Martini, E. Rudy Boersma, D. A. Janneke Dijck-Brouwer, Frits A. J. Muskiet

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

Background: Little is known about the gestational age (GA) dependent content, composition and intrauterine accretion rates of fatty acids (FA) in fetal white adipose tissue (WAT).

Objective & design: To acquire this information, we collected abdominal subcutaneous WAT samples from 40 preterm and term fetuses. Their GA ranged from 22 to 43 weeks. FA were expressed as mg/g wet WAT and g/100 g FA (g%). Intrauterine WAT FA accretion rates were estimated for appropriate (AGA) and large (LGA) for gestational age infants.

Results: From 25 to 40 weeks gestation, saturated-FA (SAFA) increased from 83 to 298 mg/g WAT and monounsaturated-FA (MUFA) from 83 to 226 mg/g WAT, while polyunsaturated-FA (PUFA) increased insignificantly from 18.0 to 23.2 mg/g WAT. As percentages of total FA, SAFA increased from 46 to 55 g%, MUFA decreased from 44 to 41 g%, and PUFA from 10.3 to 4.26 g%. Docosahexaenoic (DHA) and arachidonic acid (AA) accretion rates in WAT during the 3rd trimester for AGA infants were 88 and 193 mg/week, respectively. Contemporaneous DHA and AA accretion rates for 4500 g LGA infants were 184 and 402 mg/week, respectively. Compared to the whole 3rd trimester, increment rates during the last 5 weeks of gestation were about 2-fold higher.

Conclusion: FA accretion rates, notably those of DHA and AA, may be important for designing nutritional regiments for preterm infants. The current WAT-DHA and WAT-AA accretion rates are considerably lower than previously reported in the literature. (C) 2011 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)39-49
Number of pages11
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume86
Issue number1-2
DOIs
Publication statusPublished - 2012

Keywords

  • Intrauterine
  • Fetus
  • Fetal
  • Adipose tissue
  • Fatty acids
  • Accretion rates
  • Docosahexaenoic acid
  • Arachidonic acid
  • INFANT CEREBRAL-CORTEX
  • HUMAN BREAST-MILK
  • BODY-COMPOSITION
  • BIRTH-WEIGHT
  • AFRICAN-AMERICAN
  • HUMAN BRAIN
  • HUMAN FETUS
  • GROWTH
  • CELLULARITY
  • LACTATION

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