GlnR-mediated regulation of nitrogen metabolism in Lactococcus lactis

R Larsen, TG Kloosterman, J Kok, OP Kuipers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)
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Abstract

We show that the nitrogen regulatory protein GlnR of Lactococcus lactis represses transcription of the amtB-glnK, glnRA, and glnPQ operons. This likely occurs through a conserved DNA motif, 5'-TGTNA-7N-TN ACAT-3', and takes place in response to extracellular glutamine and ammonium. GlnR-independent repression of amtB-glnK is mediated by the pleiotropic nitrogen regulator CodY.

Original languageEnglish
Pages (from-to)4978-4982
Number of pages5
JournalJournal of Bacteriology
Volume188
Issue number13
DOIs
Publication statusPublished - Jul-2006

Keywords

  • AMINO-ACID BIOSYNTHESIS
  • BACILLUS-SUBTILIS
  • STREPTOCOCCUS-LACTIS
  • TNRA
  • GENE
  • PROMOTER
  • CODY
  • IDENTIFICATION
  • EXPRESSION
  • OPERON

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