Glucocorticosteroids Associated With a Decreased Risk of Psychosis

Wijnand Laan; Hugo Smeets; Niek J. de Wit; Rene S. Kahn; Diederick E. Grobbee; Huibert Burger

doi:10.1097/JCP.0b013e3181a44575

Glucocorticosteroids Associated With a Decreased Risk of Psychosis

Wijnand Laan^*, Hugo Smeets, Niek J. de Wit, Rene S. Kahn, Diederick E. Grobbee, Huibert Burger

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The hypothesis that chronic inflammation may play a role in psychosis receives increasing attention. In this study, we aim to investigate whether the use of steroidal anti-inflammatory drugs is associated with a decreased risk of psychosis.

A longitudinal nested case-control study was performed investigating the association of glucocorticosteroid (GCS) consumption with a new diagnosis of a psychotic disorder. Significantly reduced odds ratios of 0.52 (95% confidence interval, 0.36-0.75) were found for GCS in men only (odds ratio in women, 0.84 [95% confidence interval, 0.590-1.20]). Similar risk reductions were present for the inhaled and systemic GCSs. A dose-response relationship was present. Our finding of an inverse relation between GCS consumption and new psychotic episodes may promote further research into inflammation in schizophrenia.

Original language	English
Pages (from-to)	288-290
Number of pages	3
Journal	Journal of Clinical Psychopharmacology
Volume	29
Issue number	3
DOIs	https://doi.org/10.1097/JCP.0b013e3181a44575
Publication status	Published - Jun-2009

Keywords

schizophrenia
psychosis
inflammation
glucocorticosteroids
SCHIZOPHRENIA
CELECOXIB
THERAPY

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title = "Glucocorticosteroids Associated With a Decreased Risk of Psychosis",

abstract = "The hypothesis that chronic inflammation may play a role in psychosis receives increasing attention. In this study, we aim to investigate whether the use of steroidal anti-inflammatory drugs is associated with a decreased risk of psychosis.A longitudinal nested case-control study was performed investigating the association of glucocorticosteroid (GCS) consumption with a new diagnosis of a psychotic disorder. Significantly reduced odds ratios of 0.52 (95% confidence interval, 0.36-0.75) were found for GCS in men only (odds ratio in women, 0.84 [95% confidence interval, 0.590-1.20]). Similar risk reductions were present for the inhaled and systemic GCSs. A dose-response relationship was present. Our finding of an inverse relation between GCS consumption and new psychotic episodes may promote further research into inflammation in schizophrenia.",

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author = "Wijnand Laan and Hugo Smeets and {de Wit}, {Niek J.} and Kahn, {Rene S.} and Grobbee, {Diederick E.} and Huibert Burger",

year = "2009",

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doi = "10.1097/JCP.0b013e3181a44575",

language = "English",

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AU - Laan, Wijnand

AU - Smeets, Hugo

AU - de Wit, Niek J.

AU - Kahn, Rene S.

AU - Grobbee, Diederick E.

AU - Burger, Huibert

PY - 2009/6

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AB - The hypothesis that chronic inflammation may play a role in psychosis receives increasing attention. In this study, we aim to investigate whether the use of steroidal anti-inflammatory drugs is associated with a decreased risk of psychosis.A longitudinal nested case-control study was performed investigating the association of glucocorticosteroid (GCS) consumption with a new diagnosis of a psychotic disorder. Significantly reduced odds ratios of 0.52 (95% confidence interval, 0.36-0.75) were found for GCS in men only (odds ratio in women, 0.84 [95% confidence interval, 0.590-1.20]). Similar risk reductions were present for the inhaled and systemic GCSs. A dose-response relationship was present. Our finding of an inverse relation between GCS consumption and new psychotic episodes may promote further research into inflammation in schizophrenia.

KW - schizophrenia

KW - psychosis

KW - inflammation

KW - glucocorticosteroids

KW - SCHIZOPHRENIA

KW - CELECOXIB

KW - THERAPY

U2 - 10.1097/JCP.0b013e3181a44575

DO - 10.1097/JCP.0b013e3181a44575

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EP - 290

JO - Journal of Clinical Psychopharmacology

JF - Journal of Clinical Psychopharmacology

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ER -

Glucocorticosteroids Associated With a Decreased Risk of Psychosis

Abstract

Keywords

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