Glycans in autophagy, endocytosis and lysosomal functions

Fulvio Reggiori, Hans-Joachim Gabius, Massimo Aureli, Winfried Römer, Sandro Sonnino, Eeva-Liisa Eskelinen*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

3 Citations (Scopus)
21 Downloads (Pure)

Abstract

Glycans have been shown to function as versatile molecular signals in cells. This prompted us to look at their roles in endocytosis, endolysosomal system and autophagy. We start by introducing the cell biological aspects of these pathways, the concept of the sugar code, and provide an overview on the role of glycans in the targeting of lysosomal proteins and in lysosomal functions. Moreover, we review evidence on the regulation of endocytosis and autophagy by glycans. Finally, we discuss the emerging concept that cytosolic exposure of luminal glycans, and their detection by endogenous lectins, provides a mechanism for the surveillance of the integrity of the endolysosomal compartments, and serves their eventual repair or disposal.

Original languageEnglish
Pages (from-to)625-647
Number of pages23
JournalGlycoconjugate journal
Volume38
Issue number5
Early online date14-Aug-2021
DOIs
Publication statusPublished - Oct-2021

Keywords

  • Endolysosomal system
  • Glycoproteins
  • Glycolipids
  • Glycoconjugates
  • Lectins
  • Sugar code
  • GALACTOSIDE-BINDING-PROTEIN
  • MEMBRANE-PROTEINS
  • QUALITY-CONTROL
  • MOLECULAR-DYNAMICS
  • ATG9 TRAFFICKING
  • CYTOPLASMIC TAIL
  • O-GLCNACYLATION
  • CELL BIOLOGY
  • GALECTIN-3
  • RECEPTOR

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