Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases.

The Inflammatory Bowel Disease Biomarkers Consortium; Guinevere S.M.  . Kammeijer

doi:10.1053/j.gastro.2018.01.002

Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases.

The Inflammatory Bowel Disease Biomarkers Consortium, Guinevere S.M. . Kammeijer

Research output: Contribution to journal › Article › Academic › peer-review

86 Citations (Scopus)

Abstract

Causes of inflammatory bowel diseases are not well understood and the most prominent forms, Crohn’s disease (CD) and ulcerative colitis (UC), are sometimes hard to distinguish. Glycosylation of IgG has been associated with CD and UC. IgG Fc-glycosylation affects IgG effector functions. We evaluated changes in IgG Fc-glycosylation associated with UC and CD, as well as with disease characteristics in different patient groups.

Original language	English
Pages (from-to)	1320-1333.e10
Number of pages	24
Journal	Gastroenterology
Volume	154
Issue number	5
DOIs	https://doi.org/10.1053/j.gastro.2018.01.002
Publication status	Published - Jan-2018
Externally published	Yes

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title = "Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases.",

abstract = "Causes of inflammatory bowel diseases are not well understood and the most prominent forms, Crohn{\textquoteright}s disease (CD) and ulcerative colitis (UC), are sometimes hard to distinguish. Glycosylation of IgG has been associated with CD and UC. IgG Fc-glycosylation affects IgG effector functions. We evaluated changes in IgG Fc-glycosylation associated with UC and CD, as well as with disease characteristics in different patient groups.",

author = "{The Inflammatory Bowel Disease Biomarkers Consortium} and M {\v S}imurina and de, {Haan N} and F Vu{\v c}kovi{\'c} and NA Kennedy and J {\v S}tambuk and D Falck and I Trbojevi{\'c}-Akma{\v c}i{\'c} and F Clerc and G Razdorov and A Khon and A Latiano and R D'Inc{\`a} and S Danese and G Lauc and {. Kammeijer}, {Guinevere S.M.}",

year = "2018",

month = jan,

doi = "10.1053/j.gastro.2018.01.002",

language = "English",

volume = "154",

pages = "1320--1333.e10",

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AU - The Inflammatory Bowel Disease Biomarkers Consortium

AU - Šimurina, M

AU - de, Haan N

AU - Vučković, F

AU - Kennedy, NA

AU - Štambuk, J

AU - Falck, D

AU - Trbojević-Akmačić, I

AU - Clerc, F

AU - Razdorov, G

AU - Khon, A

AU - Latiano, A

AU - D'Incà, R

AU - Danese, S

AU - Lauc, G

AU - . Kammeijer, Guinevere S.M.

PY - 2018/1

Y1 - 2018/1

N2 - Causes of inflammatory bowel diseases are not well understood and the most prominent forms, Crohn’s disease (CD) and ulcerative colitis (UC), are sometimes hard to distinguish. Glycosylation of IgG has been associated with CD and UC. IgG Fc-glycosylation affects IgG effector functions. We evaluated changes in IgG Fc-glycosylation associated with UC and CD, as well as with disease characteristics in different patient groups.

AB - Causes of inflammatory bowel diseases are not well understood and the most prominent forms, Crohn’s disease (CD) and ulcerative colitis (UC), are sometimes hard to distinguish. Glycosylation of IgG has been associated with CD and UC. IgG Fc-glycosylation affects IgG effector functions. We evaluated changes in IgG Fc-glycosylation associated with UC and CD, as well as with disease characteristics in different patient groups.

UR - http://europepmc.org/abstract/med/29309774

U2 - 10.1053/j.gastro.2018.01.002

DO - 10.1053/j.gastro.2018.01.002

M3 - Article

C2 - 29309774

VL - 154

SP - 1320-1333.e10

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 5

ER -

Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases.

Abstract

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