Gold(I) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro

M. Serratice, B. Bertrand, E. F. J. Janssen, E. Hemelt, A. Zucca, F. Cocco, M. A. Cinellu*, A. Casini

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

A number of gold(I) complexes containing the proton pump inhibitor (PPI) lansoprazole and its reduced precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methylthio)-1H-benzo[d]imidazole have been synthesized and their biological effects have been evaluated in human cancer and nontumorigenic cells in vitro. The lansoprazole-based compounds appear to act through a V-H+-ATPase-mediated mechanism.

Original languageEnglish
Pages (from-to)1418-1422
Number of pages5
JournalMedChemComm
Volume5
Issue number9
DOIs
Publication statusPublished - Sep-2014

Keywords

  • PROTON-PUMP INHIBITORS
  • ANTIPROLIFERATIVE PROPERTIES
  • SOLUTION BEHAVIOR
  • COMPLEXES
  • RESISTANCE
  • CHEMISTRY
  • TARGETS
  • SERIES
  • AGENTS
  • TUMORS

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