Abstract
BACKGROUND/AIM: Therapeutic interventions in nonalcoholic fatty liver disease are limited, while anti-oxidative materials have shown benefits in animal models. This study aimed to evaluate grape seed extract as an anti-oxidative material in this process. Therapeutic effects of grape seed extract were evaluated in comparison to vitamin C in a double-blind setting.
MATERIALS AND METHODS: Fifteen patients were enrolled in each group. Liver function tests were done; also, grade of steatosis and pattern of echogenicity of the liver were determined. Patients were followed up by the same evaluation repeated in first, second and third months.
RESULTS: Mean age +/- standard deviation was 43.2 +/- 10.3 years. Grape seed extract (GSE) significantly improved the grade of fatty liver change; and resulted in significant decrease in alanine aminotransferase in patients receiving the concentrate compared to those receiving vitamin C independently, from the initial grade of steatosis.
CONCLUSIONS: This study describes the beneficial effect of using grape seed extract for three months in patients with nonalcoholic fatty liver disease. These results may improve with a longer period of follow-up.
| Original language | English |
|---|---|
| Pages (from-to) | 194-197 |
| Number of pages | 4 |
| Journal | Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association |
| Volume | 16 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 10-Jul-2010 |
| Externally published | Yes |
Keywords
- Adult
- Alanine Transaminase
- Analysis of Variance
- Antioxidants
- Ascorbic Acid
- Case-Control Studies
- Chi-Square Distribution
- Fatty Liver
- Female
- Grape Seed Extract
- Humans
- Liver Function Tests
- Male
- Oxidative Stress
- Treatment Outcome
- Comparative Study
- Journal Article
- Research Support, Non-U.S. Gov't