Growth hormone replacement does not elevate albuminuria in GH-deficient adults

JAM Beentjes, RPF Dullaart*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    Minor elevations in urinary albumin excretion rate (Ualb.V) are likely to be associated with renal function loss and increased cardiovascular risk. Since urinary albumin excretion is affected by the growth hormone (GH)-insulin-like growth factor-1 (IGF-1) axis, we evaluated the effect of 6 months GH replacement (1 U/day, n = 8 and 2 U/day, n = 16) on urinary protein handling in 24 nondiabetic, normotensive GII-deficient adults (12 men and 12 women), of whom 8 patients received placebo during 6 months, followed by active GH treatment. Plasma IGF-1 increased from 11.4 (8.1-15.8) nmol/L (median, interquartile range) to 35.4 (22.3-44.1) nmol/L (p 0.10). Likewise, urinary IgG excretion rate did not significantly change after GH (0.71 (0.52-1.20) mug/min before GH versus 0.80 (0.51-1.56) mug/min after GH; p>0.10). No significant changes were observed in creatinine clearance (p>0.10) and mean arterial pressure (p>0.10). No changes in any of these parameters were observed after placebo. Individual changes in Ualb.V were positively correlated with changes in plasma IGF-I (r(s) = 0.41, p = 0.05) and with changes in mean arterial pressure (r(s) = 0.49, p <0.02). The present study shows that 6 months GH replacement, increasing plasma IGF-1 within the physiological range, does not result in a clinically relevant increase in urinary protein excretion in GH-deficient adults. The correlation between changes in plasma IGF-1 and in albuminuria supports the rationale to avoid supraphysiological IGF-1 levels.

    Original languageEnglish
    Pages (from-to)1-6
    Number of pages6
    JournalScandinavian Journal of Clinical & Laboratory Investigation
    Volume62
    Issue number1
    Publication statusPublished - 2002

    Keywords

    • growth hormone deficiency
    • growth hormone treatment
    • kidney function
    • microalbuminuria
    • urinary albumin excretion
    • urinary IgG excretion
    • DEPENDENT DIABETIC-PATIENTS
    • FACTOR-I
    • SOMATOSTATIN ANALOG
    • RENAL HEMODYNAMICS
    • KIDNEY-FUNCTION
    • MICROALBUMINURIA
    • EXCRETION
    • CHILDREN
    • SIZE

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