Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and older

Chris J L M Meijer*, Johannes Berkhof, Philip E Castle, Albertus T Hesselink, Eduardo L Franco, Guglielmo Ronco, Marc Arbyn, F Xavier Bosch, Jack Cuzick, Joakim Dillner, Daniëlle A M Heideman, Peter J F Snijders

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

565 Citations (Scopus)

Abstract

Given the strong etiologic link between high-risk HPV infection and cervical cancer high-risk HPV testing is now being considered as an alternative for cytology-based cervical cancer screening. Many test systems have been developed that can detect the broad spectrum of hrHPV types in one assay. However, for screening purposes the detection of high-risk HPV is not inherently useful unless it is informative for the presence of high-grade cervical intraepithelial neoplasia (CIN 2/3) or cancer. Candidate high-risk HPV tests to be used for screening should reach an optimal balance between clinical sensitivity and specificity for detection of high-grade CIN and cervical cancer to minimize redundant or excessive follow-up procedures for high-risk HPV positive women without cervical lesions. Data from various large screening studies have shown that high-risk HPV testing by hybrid capture 2 and GP5+/6+-PCR yields considerably better results in the detection of CIN 2/3 than cytology. The data from these studies can be used to guide the translation of high-risk HPV testing into clinical practice by setting standards of test performance and characteristics. On the basis of these data we have developed guidelines for high-risk HPV test requirements for primary cervical screening and validation guidelines for candidate HPV assays.

Original languageEnglish
Pages (from-to)516-520
Number of pages5
JournalInternational Journal of Cancer
Volume124
Issue number3
DOIs
Publication statusPublished - 1-Feb-2009
Externally publishedYes

Keywords

  • Adult
  • Female
  • Guidelines as Topic
  • Humans
  • Mass Screening/methods
  • Papillomavirus Infections/complications
  • Polymerase Chain Reaction
  • Sensitivity and Specificity
  • Uterine Cervical Neoplasms/diagnosis
  • Uterine Cervical Dysplasia/diagnosis

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