Hair cell mechano-transduction: Its influence on the gross mechanical characteristics of a hair cell sense organ

Sietse M. van Netten*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Abstract

The complex mechanical behaviour of a hair cell bundle appears to be a direct consequence of the gating forces on the individual transduction channels. The mechanical molecular interactions involved in transduction channel gating, therefore, also bear a reciprocal influence, via the hair bundles; on the mechanical properties of accessory structures driving them. This allows for the possibility to investigate, under in vivo conditions, the mechanical gating machinery of ion channels via the dynamics of accessory structures. We have performed such studies on the lateral line relate the mechanics of elementary molecular events to the macroscopical dynamics of an intact organ. (C) 1997 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)43-52
Number of pages10
JournalProgress in Biophysics & Molecular Biology
Volume68
Issue number1-3
DOIs
Publication statusPublished - Oct-1997
Event12th International Biophysics Congress - , Netherlands
Duration: 12-Aug-199616-Aug-1996

Keywords

  • hair cells
  • mechano-electrical transduction
  • hair bundle micromechanics
  • tectorial structure mechanics
  • mechanical tuning
  • lateral line
  • FISH LATERAL-LINE
  • MECHANOELECTRICAL TRANSDUCTION
  • BULLFROGS SACCULUS
  • INNER-EAR
  • CHANNELS
  • CUPULA
  • ADAPTATION
  • BUNDLES
  • STEREOCILIA
  • SITE

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