Hairy cell leukemia preferentially expresses the IgG3-subclass

H C Kluin-Nelemans; M M Krouwels; J H Jansen; K Dijkstra; M J van Tol; G J den Ottolander; E J Dreef; P M Kluin

Hairy cell leukemia preferentially expresses the IgG3-subclass

H C Kluin-Nelemans, M M Krouwels, J H Jansen, K Dijkstra, M J van Tol, G J den Ottolander, E J Dreef, P M Kluin

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Abstract

Surface IgG expression of 29 cases of hairy cell leukemia (HCL) was assessed using IgG-subclass-specific monoclonal and F(ab)'2 polyclonal antibodies. A marked preference for the IgG3 subclass was found, as 16 of 19 IgG-positive HCL's expressed IgG3. In 10 cases, IgG3 was concurrently expressed with other heavy chains. No preferential IgG3 expression was observed in 11 IgG-positive non-Hodgkin's lymphomas. The marked predominance of IgG3 in HCL suggests a deviation in heavy chain class switching that may be related to the characteristically very low expression of LFA-1 and ICAM-1 molecules on hairy cells, and hence a defect in T-cell hairy cell interaction.

Original language	English
Pages (from-to)	972-5
Number of pages	4
Journal	Blood
Volume	75
Issue number	4
Publication status	Published - 15-Feb-1990
Externally published	Yes

Keywords

Antigens, Differentiation
Fluorescent Antibody Technique
Humans
Immunoglobulin G
Leukemia, Hairy Cell
Receptors, Fc
Receptors, IgG

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title = "Hairy cell leukemia preferentially expresses the IgG3-subclass",

abstract = "Surface IgG expression of 29 cases of hairy cell leukemia (HCL) was assessed using IgG-subclass-specific monoclonal and F(ab)'2 polyclonal antibodies. A marked preference for the IgG3 subclass was found, as 16 of 19 IgG-positive HCL's expressed IgG3. In 10 cases, IgG3 was concurrently expressed with other heavy chains. No preferential IgG3 expression was observed in 11 IgG-positive non-Hodgkin's lymphomas. The marked predominance of IgG3 in HCL suggests a deviation in heavy chain class switching that may be related to the characteristically very low expression of LFA-1 and ICAM-1 molecules on hairy cells, and hence a defect in T-cell hairy cell interaction.",

keywords = "Antigens, Differentiation, Fluorescent Antibody Technique, Humans, Immunoglobulin G, Leukemia, Hairy Cell, Receptors, Fc, Receptors, IgG",

author = "Kluin-Nelemans, {H C} and Krouwels, {M M} and Jansen, {J H} and K Dijkstra and {van Tol}, {M J} and {den Ottolander}, {G J} and Dreef, {E J} and Kluin, {P M}",

year = "1990",

month = feb,

day = "15",

language = "English",

volume = "75",

pages = "972--5",

journal = "Blood",

issn = "0006-4971",

publisher = "AMER SOC HEMATOLOGY",

number = "4",

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TY - JOUR

T1 - Hairy cell leukemia preferentially expresses the IgG3-subclass

AU - Kluin-Nelemans, H C

AU - Krouwels, M M

AU - Jansen, J H

AU - Dijkstra, K

AU - van Tol, M J

AU - den Ottolander, G J

AU - Dreef, E J

AU - Kluin, P M

PY - 1990/2/15

Y1 - 1990/2/15

N2 - Surface IgG expression of 29 cases of hairy cell leukemia (HCL) was assessed using IgG-subclass-specific monoclonal and F(ab)'2 polyclonal antibodies. A marked preference for the IgG3 subclass was found, as 16 of 19 IgG-positive HCL's expressed IgG3. In 10 cases, IgG3 was concurrently expressed with other heavy chains. No preferential IgG3 expression was observed in 11 IgG-positive non-Hodgkin's lymphomas. The marked predominance of IgG3 in HCL suggests a deviation in heavy chain class switching that may be related to the characteristically very low expression of LFA-1 and ICAM-1 molecules on hairy cells, and hence a defect in T-cell hairy cell interaction.

AB - Surface IgG expression of 29 cases of hairy cell leukemia (HCL) was assessed using IgG-subclass-specific monoclonal and F(ab)'2 polyclonal antibodies. A marked preference for the IgG3 subclass was found, as 16 of 19 IgG-positive HCL's expressed IgG3. In 10 cases, IgG3 was concurrently expressed with other heavy chains. No preferential IgG3 expression was observed in 11 IgG-positive non-Hodgkin's lymphomas. The marked predominance of IgG3 in HCL suggests a deviation in heavy chain class switching that may be related to the characteristically very low expression of LFA-1 and ICAM-1 molecules on hairy cells, and hence a defect in T-cell hairy cell interaction.

KW - Antigens, Differentiation

KW - Fluorescent Antibody Technique

KW - Humans

KW - Immunoglobulin G

KW - Leukemia, Hairy Cell

KW - Receptors, Fc

KW - Receptors, IgG

M3 - Article

C2 - 2137355

SN - 0006-4971

VL - 75

SP - 972

EP - 975

JO - Blood

JF - Blood

IS - 4

ER -

Hairy cell leukemia preferentially expresses the IgG3-subclass

Abstract

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