Hard-Wired Control of Bacterial Processes by Chromosomal Gene Location

Jelle Slager, Jan-Willem Veening

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Bacterial processes, such as stress responses and cell differentiation, are controlled at many different levels. While some factors, such as transcriptional regulation, are well appreciated, the importance of chromosomal gene location is often underestimated or even completely neglected. A combination of environmental parameters and the chromosomal location of a gene determine how many copies of its DNA are present at a given time during the cell cycle. Here, we review bacterial processes that rely, completely or partially, on the chromosomal location of involved genes and their fluctuating copy numbers. Special attention will be given to the several different ways in which these copy-number fluctuations can be used for bacterial cell fate determination or coordination of interdependent processes in a bacterial cell.

Original languageEnglish
Article numberTIMI 1345
Pages (from-to)788-800
Number of pages13
JournalTrends in Microbiology
Issue number10
Publication statusPublished - Oct-2016


  • DNA replication
  • chromosome organization
  • stress response
  • cell fate determination
  • gene dosage
  • Bacillus subtilis
  • Streptococcus pneumoniae
  • Vibrio cholera

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