46 Citations (Scopus)

Abstract

BACKGROUND: High-density lipoproteins (HDLs) protect against the development of atherosclerotic cardiovascular disease. HDL function represents an emerging concept in cardiovascular research.

OBJECTIVE: This study investigated the association between HDL functionality and acute myocardial infarction (MI) independent of HDL-cholesterol plasma levels.

METHODS: Participants (non-ST-segment elevation MI, non-STEMI, n = 41; STEMI, n = 37; non MI patients, n = 33) from a prospective follow-up study enrolling patients with acute chest pain were matched for age and plasma HDL cholesterol. The in vitro capacity of HDL to (1) mediate cholesterol efflux from macrophage foam cells, (2) prevent low-density lipoprotein oxidation, and (3) inhibit TNF-alpha-induced vascular adhesion molecule-1 expression in endothelial cells was determined.

RESULTS: STEMI-HDL displayed reduced cholesterol efflux (P

CONCLUSION: Independent of plasma HDL cholesterol levels, 2 of 3 antiatherogenic HDL functionalities tested were significantly impaired in STEMI patients, namely cholesterol efflux and antiinflammatory properties. Increased myeloperoxidase levels might represent a major contributing mechanism for decreased HDL functionality in MI patients. (C) 2016 National Lipid Association. All rights reserved.

Original languageEnglish
Pages (from-to)1318-1328
Number of pages11
JournalJournal of Clinical Lipidology
Volume10
Issue number6
DOIs
Publication statusPublished - Dec-2016

Keywords

  • Acute coronary syndrome
  • Cholesterol
  • Cholesterol efflux
  • HDL function
  • Inflammation
  • Oxidation
  • HIGH-DENSITY-LIPOPROTEIN
  • SECRETORY PHOSPHOLIPASE A(2)
  • TYPE-2 DIABETES-MELLITUS
  • CORONARY-ARTERY-DISEASE
  • CHEST-PAIN
  • ANTIOXIDATIVE CAPACITY
  • INHIBITS 3
  • IN-VIVO
  • MYELOPEROXIDASE
  • TRANSPORT

Cite this