HE4 Serum Levels Are Associated with Heart Failure Severity in Patients With Chronic Heart Failure

Arnold Piek; Wouter C. Meijers; Nicolas F. Schroten; Ron T. Gansevoort; Rudolf A. de Boer; Herman H. W. Sillje

doi:10.1016/j.cardfail.2016.05.002

HE4 Serum Levels Are Associated with Heart Failure Severity in Patients With Chronic Heart Failure

Arnold Piek, Wouter C. Meijers, Nicolas F. Schroten, Ron T. Gansevoort, Rudolf A. de Boer, Herman H. W. Sillje^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: The novel biomarker human epididymis protein 4 (HE4) shows prognostic value in acute heart failure (HF) patients. We measured HE4 levels in patients with chronic heart failure (CHF) and correlated them to HF severity, kidney function, and HF biomarkers, and determined its predictive value.

Methods: Serum HE4 levels in patients (n = 101) with stable CHF with reduced left ventricular ejection fraction (LVEF

Results: HE4 levels were higher in CHF compared with control subjects (69.2 pmol/L [interquartile range 55.6-93.8] vs 56.1 pmol/L [46.6-69.0]; P

Conclusions: HE4 levels are increased in CHF, correlate with HF severity and kidney function, and predict HF outcome.

Original language	English
Pages (from-to)	12-19
Number of pages	8
Journal	Journal of Cardiac Failure
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.cardfail.2016.05.002
Publication status	Published - Jan-2017

Keywords

HE4
WFDC2
chronic heart failure
fibrosis
EPIDIDYMIS PROTEIN 4
TASK-FORCE
GUIDELINES
PROGNOSIS
DIAGNOSIS
BIOMARKER

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HE4 Serum Levels Are Associated with Heart Failure SeverityFinal publisher's version, 369 KBLicence: CC BY

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@article{5638e6757ae142fea80a1c5c5a75fa3a,

title = "HE4 Serum Levels Are Associated with Heart Failure Severity in Patients With Chronic Heart Failure",

abstract = "Background: The novel biomarker human epididymis protein 4 (HE4) shows prognostic value in acute heart failure (HF) patients. We measured HE4 levels in patients with chronic heart failure (CHF) and correlated them to HF severity, kidney function, and HF biomarkers, and determined its predictive value.Methods: Serum HE4 levels in patients (n = 101) with stable CHF with reduced left ventricular ejection fraction (LVEFResults: HE4 levels were higher in CHF compared with control subjects (69.2 pmol/L [interquartile range 55.6-93.8] vs 56.1 pmol/L [46.6-69.0]; PConclusions: HE4 levels are increased in CHF, correlate with HF severity and kidney function, and predict HF outcome.",

keywords = "HE4, WFDC2, chronic heart failure, fibrosis, EPIDIDYMIS PROTEIN 4, TASK-FORCE, GUIDELINES, PROGNOSIS, DIAGNOSIS, BIOMARKER",

author = "Arnold Piek and Meijers, {Wouter C.} and Schroten, {Nicolas F.} and Gansevoort, {Ron T.} and {de Boer}, {Rudolf A.} and Sillje, {Herman H. W.}",

year = "2017",

month = jan,

doi = "10.1016/j.cardfail.2016.05.002",

language = "English",

volume = "23",

pages = "12--19",

journal = "Journal of Cardiac Failure",

issn = "1071-9164",

publisher = "Churchill Livingstone",

number = "1",

}

TY - JOUR

T1 - HE4 Serum Levels Are Associated with Heart Failure Severity in Patients With Chronic Heart Failure

AU - Piek, Arnold

AU - Meijers, Wouter C.

AU - Schroten, Nicolas F.

AU - Gansevoort, Ron T.

AU - de Boer, Rudolf A.

AU - Sillje, Herman H. W.

PY - 2017/1

Y1 - 2017/1

N2 - Background: The novel biomarker human epididymis protein 4 (HE4) shows prognostic value in acute heart failure (HF) patients. We measured HE4 levels in patients with chronic heart failure (CHF) and correlated them to HF severity, kidney function, and HF biomarkers, and determined its predictive value.Methods: Serum HE4 levels in patients (n = 101) with stable CHF with reduced left ventricular ejection fraction (LVEFResults: HE4 levels were higher in CHF compared with control subjects (69.2 pmol/L [interquartile range 55.6-93.8] vs 56.1 pmol/L [46.6-69.0]; PConclusions: HE4 levels are increased in CHF, correlate with HF severity and kidney function, and predict HF outcome.

AB - Background: The novel biomarker human epididymis protein 4 (HE4) shows prognostic value in acute heart failure (HF) patients. We measured HE4 levels in patients with chronic heart failure (CHF) and correlated them to HF severity, kidney function, and HF biomarkers, and determined its predictive value.Methods: Serum HE4 levels in patients (n = 101) with stable CHF with reduced left ventricular ejection fraction (LVEFResults: HE4 levels were higher in CHF compared with control subjects (69.2 pmol/L [interquartile range 55.6-93.8] vs 56.1 pmol/L [46.6-69.0]; PConclusions: HE4 levels are increased in CHF, correlate with HF severity and kidney function, and predict HF outcome.

KW - HE4

KW - WFDC2

KW - chronic heart failure

KW - fibrosis

KW - EPIDIDYMIS PROTEIN 4

KW - TASK-FORCE

KW - GUIDELINES

KW - PROGNOSIS

KW - DIAGNOSIS

KW - BIOMARKER

U2 - 10.1016/j.cardfail.2016.05.002

DO - 10.1016/j.cardfail.2016.05.002

M3 - Article

SN - 1071-9164

VL - 23

SP - 12

EP - 19

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

IS - 1

ER -

HE4 Serum Levels Are Associated with Heart Failure Severity in Patients With Chronic Heart Failure

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