Health economics of blood transfusion safety - focus on sub-Saharan Africa

Marinus van Hulst*, Cees Th. Smit Smit Sibinga, Maarten J. Postma

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)
507 Downloads (Pure)

Abstract

Background and objectives. Health economics provides a standardised methodology for valid comparisons of interventions in different fields of health care. This review discusses the health economic evaluations of strategies to enhance blood product safety in sub-Saharan Africa

Methods. We reviewed health economic methodology with special reference to cost-effectiveness analysis We searched the literature for cost-effectiveness in blood product safety in sub-Saharan Africa.

Result HIV-antibody screening in different settings in sub-Saharan Africa showed health gains and saved costs Except for adding HIV-p24 screening, adding other tests such as nucleic acid amplification testing (NAT) to HIV-antibody screening displayed incremental cost-effectiveness ratios greater than the WHO/World Bank specified threshold for cost-effectiveness. The addition of HIV-p24 in combination with HCV antibody/antigen screening and multiplex (HBV, HCV and HIV) NAT in pools of 24 may also be cost-effective options for Ghana

Conclusions From a health economic viewpoint. HIV-antibody screening should always be implemented in sub-Saharan Africa. The addition of HIV-p24 antigen screening, in combination with HCV antibody/antigen screening and multiplex (HBV. HCV and HIV) NAT in pools of 24 may be feasible options for Ghana. Suggestions for future health economic evaluations of blood transfusion safety interventions in sub-Saharan Africa are mis-transfusion, laboratory quality and donor management.(C) 2009 The International Association for Biologicals Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalBiologicals
Volume38
Issue number1
DOIs
Publication statusPublished - Jan-2010

Keywords

  • Health economics
  • HIV
  • HCV
  • HBV
  • Transfusion
  • Cost-effectiveness
  • Screening
  • Developing countries
  • COST-EFFECTIVENESS ANALYSIS
  • HEPATITIS-C VIRUS
  • WEST-NILE-VIRUS
  • QUALITY-OF-LIFE
  • PRODUCTIVITY COSTS
  • HIV TRANSMISSION
  • MEDICINE
  • RISK
  • DONORS
  • CONSEQUENCES

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