Health-related quality of life and late morbidity in concurrent chemoradiation and radiotherapy alone in patients with locally advanced cervical carcinoma

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Abstract

Objective: Concurrent chemoradiation has improved survival of patients with cervical carcinoma. However, follow-up of randomized studies is relatively short and data on long term toxicity are scarce, as is information on their health-related quality of life. This study assesses and compares incidences of late side-effects among patients treated with radiotherapy or chemoradiation using two toxicity scoring systems, and investigates impact on health-related quality of life.

Methods: Between 1985 and 1993, 114 patients underwent radiotherapy (n=39) or chemoradiation (n=75) for stage IIA-IVB cervical carcinoma. Late side-effects were scored retrospectively by reviewing medical charts using standardised checklists, focusing on bladder- and intestinal side effects. Health-related quality of life was assessed once using the EORTC QLQ-C30.

Results: No significant differences in late treatment-related side-effects between radiotherapy and chemoradiation groups were found. Grade >= 2 toxicity was found in 33% (bladder), and in 6% (bowel). Only 1.8% had both grade 3-4 toxicity. Bladder syndrome with high urinary frequency, urine incontinence and small bowel toxicity had a significant impact on health-related quality of life.

Conclusion: Grade 2 are relatively frequent late side effects in curatively treated patients, but are not enhanced by the addition of chemotherapy. Their negative impact on health-related quality of life stresses the importance of new radiation techniques, aiming at reduction of these side effects.

Original languageEnglish
Pages (from-to)152-160
Number of pages9
JournalJournal of gynecologic oncology
Volume22
Issue number3
DOIs
Publication statusPublished - Sep-2011

Keywords

  • Cervical carcinoma
  • Concurrent radiochemotherapy
  • Late treatment-related morbidity
  • Radiotherapy
  • RADIATION-THERAPY
  • TOXICITY CRITERIA
  • WEEKLY CISPLATIN
  • CANCER-TREATMENT
  • CHEMOTHERAPY
  • CHEMORADIOTHERAPY
  • METAANALYSIS
  • SURVIVAL
  • BLADDER
  • RECTUM

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