Health-related quality of life in older patients surviving ICU treatment for COVID-19: results from an international observational study of patients older than 70 years

COVIP study group; Ivo W Soliman; Susannah Leaver; Hans Flaatten; Jesper Fjølner; Bernhard Wernly; Raphael R Bruno; Antonio Artigas; Bernardo Bollen Pinto; Joerg C Schefold; Michael Beil; Sigal Sviri; Peter Vernon van Heerden; Wojciech Szczeklik; Muhammed Elhadi; Michael Joannidis; Sandra Oeyen; Tilemachos Zafeiridis; Jakob Wollborn; Maria Jose Arche Banzo; Kristina Fuest; Brian Marsh; Finn H Andersen; Rui Moreno; Ariane Boumendil; Bertrand Guidet; Christian Jung; Dylan W De Lange

doi:10.1093/ageing/afab278

Health-related quality of life in older patients surviving ICU treatment for COVID-19: results from an international observational study of patients older than 70 years

COVIP study group, Ivo W Soliman, Susannah Leaver, Hans Flaatten, Jesper Fjølner, Bernhard Wernly, Raphael R Bruno, Antonio Artigas, Bernardo Bollen Pinto, Joerg C Schefold, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Jakob Wollborn, Maria Jose Arche BanzoKristina Fuest, Brian Marsh, Finn H Andersen, Rui Moreno, Ariane Boumendil, Bertrand Guidet, Christian Jung, Dylan W De Lange

Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

98 Downloads (Pure)

Abstract

BACKGROUND: health-related quality of life (HRQoL) is an important patient-centred outcome in patients surviving ICU admission for COVID-19. It is currently not clear which domains of the HRQoL are most affected.

OBJECTIVE: to quantify HRQoL in order to identify areas of interventions.

DESIGN: prospective observation study.

SETTING: admissions to European ICUs between March 2020 and February 2021.

SUBJECTS: patients aged 70 years or older admitted with COVID-19 disease.

METHODS: collected determinants include SOFA-score, Clinical Frailty Scale (CFS), number and timing of ICU procedures and limitation of care, Katz Activities of Daily Living (ADL) dependence score. HRQoL was assessed at 3 months after ICU admission with the Euro-QoL-5D-5L questionnaire. An outcome of ≥4 on any of Euro-QoL-5D-5L domains was considered unfavourable.

RESULTS: in total 3,140 patients from 14 European countries were included in this study. Three months after inclusion, 1,224 patients (39.0%) were alive and the EQ-5D-5L from was obtained. The CFS was associated with an increased odds ratio for an unfavourable HRQoL outcome after 3 months; OR 1.15 (95% confidence interval (CI): 0.71-1.87) for CFS 2 to OR 4.33 (95% CI: 1.57-11.9) for CFS ≧ 7. The Katz ADL was not statistically significantly associated with HRQoL after 3 months.

CONCLUSIONS: in critically ill old intensive care patients suffering from COVID-19, the CFS is associated with the subjectively perceived quality of life. The CFS on admission can be used to inform patients and relatives on the risk of an unfavourable qualitative outcome if such patients survive.

Original language	English
Article number	afab278
Number of pages	10
Journal	Age and Ageing
Volume	51
Issue number	2
DOIs	https://doi.org/10.1093/ageing/afab278
Publication status	Published - 1-Feb-2022

Keywords

Activities of Daily Living
Aged
COVID-19
Humans
Intensive Care Units
Prospective Studies
Quality of Life
SARS-CoV-2

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COVIP study group, Soliman, I. W., Leaver, S., Flaatten, H., Fjølner, J., Wernly, B., Bruno, R. R., Artigas, A., Bollen Pinto, B., Schefold, J. C., Beil, M., Sviri, S., van Heerden, P. V., Szczeklik, W., Elhadi, M., Joannidis, M., Oeyen, S., Zafeiridis, T., Wollborn, J., ... De Lange, D. W. (2022). Health-related quality of life in older patients surviving ICU treatment for COVID-19: results from an international observational study of patients older than 70 years. Age and Ageing, 51(2), Article afab278. https://doi.org/10.1093/ageing/afab278

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title = "Health-related quality of life in older patients surviving ICU treatment for COVID-19: results from an international observational study of patients older than 70 years",

abstract = "BACKGROUND: health-related quality of life (HRQoL) is an important patient-centred outcome in patients surviving ICU admission for COVID-19. It is currently not clear which domains of the HRQoL are most affected.OBJECTIVE: to quantify HRQoL in order to identify areas of interventions.DESIGN: prospective observation study.SETTING: admissions to European ICUs between March 2020 and February 2021.SUBJECTS: patients aged 70 years or older admitted with COVID-19 disease.METHODS: collected determinants include SOFA-score, Clinical Frailty Scale (CFS), number and timing of ICU procedures and limitation of care, Katz Activities of Daily Living (ADL) dependence score. HRQoL was assessed at 3 months after ICU admission with the Euro-QoL-5D-5L questionnaire. An outcome of ≥4 on any of Euro-QoL-5D-5L domains was considered unfavourable.RESULTS: in total 3,140 patients from 14 European countries were included in this study. Three months after inclusion, 1,224 patients (39.0%) were alive and the EQ-5D-5L from was obtained. The CFS was associated with an increased odds ratio for an unfavourable HRQoL outcome after 3 months; OR 1.15 (95% confidence interval (CI): 0.71-1.87) for CFS 2 to OR 4.33 (95% CI: 1.57-11.9) for CFS ≧ 7. The Katz ADL was not statistically significantly associated with HRQoL after 3 months.CONCLUSIONS: in critically ill old intensive care patients suffering from COVID-19, the CFS is associated with the subjectively perceived quality of life. The CFS on admission can be used to inform patients and relatives on the risk of an unfavourable qualitative outcome if such patients survive.",

keywords = "Activities of Daily Living, Aged, COVID-19, Humans, Intensive Care Units, Prospective Studies, Quality of Life, SARS-CoV-2",

author = "{COVIP study group} and Soliman, {Ivo W} and Susannah Leaver and Hans Flaatten and Jesper Fj{\o}lner and Bernhard Wernly and Bruno, {Raphael R} and Antonio Artigas and {Bollen Pinto}, Bernardo and Schefold, {Joerg C} and Michael Beil and Sigal Sviri and {van Heerden}, {Peter Vernon} and Wojciech Szczeklik and Muhammed Elhadi and Michael Joannidis and Sandra Oeyen and Tilemachos Zafeiridis and Jakob Wollborn and Banzo, {Maria Jose Arche} and Kristina Fuest and Brian Marsh and Andersen, {Finn H} and Rui Moreno and Ariane Boumendil and Bertrand Guidet and Christian Jung and {De Lange}, {Dylan W} and Willem Dieperink",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s) 2022.",

year = "2022",

month = feb,

day = "1",

doi = "10.1093/ageing/afab278",

language = "English",

volume = "51",

journal = "Age and Ageing",

issn = "0002-0729",

publisher = "Oxford University Press",

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COVIP study group, Soliman, IW, Leaver, S, Flaatten, H, Fjølner, J, Wernly, B, Bruno, RR, Artigas, A, Bollen Pinto, B, Schefold, JC, Beil, M, Sviri, S, van Heerden, PV, Szczeklik, W, Elhadi, M, Joannidis, M, Oeyen, S, Zafeiridis, T, Wollborn, J, Banzo, MJA, Fuest, K, Marsh, B, Andersen, FH, Moreno, R, Boumendil, A, Guidet, B, Jung, C & De Lange, DW 2022, 'Health-related quality of life in older patients surviving ICU treatment for COVID-19: results from an international observational study of patients older than 70 years', Age and Ageing, vol. 51, no. 2, afab278. https://doi.org/10.1093/ageing/afab278

TY - JOUR

T1 - Health-related quality of life in older patients surviving ICU treatment for COVID-19

T2 - results from an international observational study of patients older than 70 years

AU - COVIP study group

AU - Soliman, Ivo W

AU - Leaver, Susannah

AU - Flaatten, Hans

AU - Fjølner, Jesper

AU - Wernly, Bernhard

AU - Bruno, Raphael R

AU - Artigas, Antonio

AU - Bollen Pinto, Bernardo

AU - Schefold, Joerg C

AU - Beil, Michael

AU - Sviri, Sigal

AU - van Heerden, Peter Vernon

AU - Szczeklik, Wojciech

AU - Elhadi, Muhammed

AU - Joannidis, Michael

AU - Oeyen, Sandra

AU - Zafeiridis, Tilemachos

AU - Wollborn, Jakob

AU - Banzo, Maria Jose Arche

AU - Fuest, Kristina

AU - Marsh, Brian

AU - Andersen, Finn H

AU - Moreno, Rui

AU - Boumendil, Ariane

AU - Guidet, Bertrand

AU - Jung, Christian

AU - De Lange, Dylan W

AU - Dieperink, Willem

PY - 2022/2/1

Y1 - 2022/2/1

N2 - BACKGROUND: health-related quality of life (HRQoL) is an important patient-centred outcome in patients surviving ICU admission for COVID-19. It is currently not clear which domains of the HRQoL are most affected.OBJECTIVE: to quantify HRQoL in order to identify areas of interventions.DESIGN: prospective observation study.SETTING: admissions to European ICUs between March 2020 and February 2021.SUBJECTS: patients aged 70 years or older admitted with COVID-19 disease.METHODS: collected determinants include SOFA-score, Clinical Frailty Scale (CFS), number and timing of ICU procedures and limitation of care, Katz Activities of Daily Living (ADL) dependence score. HRQoL was assessed at 3 months after ICU admission with the Euro-QoL-5D-5L questionnaire. An outcome of ≥4 on any of Euro-QoL-5D-5L domains was considered unfavourable.RESULTS: in total 3,140 patients from 14 European countries were included in this study. Three months after inclusion, 1,224 patients (39.0%) were alive and the EQ-5D-5L from was obtained. The CFS was associated with an increased odds ratio for an unfavourable HRQoL outcome after 3 months; OR 1.15 (95% confidence interval (CI): 0.71-1.87) for CFS 2 to OR 4.33 (95% CI: 1.57-11.9) for CFS ≧ 7. The Katz ADL was not statistically significantly associated with HRQoL after 3 months.CONCLUSIONS: in critically ill old intensive care patients suffering from COVID-19, the CFS is associated with the subjectively perceived quality of life. The CFS on admission can be used to inform patients and relatives on the risk of an unfavourable qualitative outcome if such patients survive.

AB - BACKGROUND: health-related quality of life (HRQoL) is an important patient-centred outcome in patients surviving ICU admission for COVID-19. It is currently not clear which domains of the HRQoL are most affected.OBJECTIVE: to quantify HRQoL in order to identify areas of interventions.DESIGN: prospective observation study.SETTING: admissions to European ICUs between March 2020 and February 2021.SUBJECTS: patients aged 70 years or older admitted with COVID-19 disease.METHODS: collected determinants include SOFA-score, Clinical Frailty Scale (CFS), number and timing of ICU procedures and limitation of care, Katz Activities of Daily Living (ADL) dependence score. HRQoL was assessed at 3 months after ICU admission with the Euro-QoL-5D-5L questionnaire. An outcome of ≥4 on any of Euro-QoL-5D-5L domains was considered unfavourable.RESULTS: in total 3,140 patients from 14 European countries were included in this study. Three months after inclusion, 1,224 patients (39.0%) were alive and the EQ-5D-5L from was obtained. The CFS was associated with an increased odds ratio for an unfavourable HRQoL outcome after 3 months; OR 1.15 (95% confidence interval (CI): 0.71-1.87) for CFS 2 to OR 4.33 (95% CI: 1.57-11.9) for CFS ≧ 7. The Katz ADL was not statistically significantly associated with HRQoL after 3 months.CONCLUSIONS: in critically ill old intensive care patients suffering from COVID-19, the CFS is associated with the subjectively perceived quality of life. The CFS on admission can be used to inform patients and relatives on the risk of an unfavourable qualitative outcome if such patients survive.

KW - Activities of Daily Living

KW - Aged

KW - COVID-19

KW - Humans

KW - Intensive Care Units

KW - Prospective Studies

KW - Quality of Life

KW - SARS-CoV-2

U2 - 10.1093/ageing/afab278

DO - 10.1093/ageing/afab278

M3 - Article

C2 - 35136896

SN - 0002-0729

VL - 51

JO - Age and Ageing

JF - Age and Ageing

IS - 2

M1 - afab278

ER -