Health-related quality of life is linked to the gut microbiome in kidney transplant recipients

TransplantLines Investigators; J. Casper Swarte; Tim J. Knobbe; Johannes R Björk; Ranko Gacesa; Lianne M. Nieuwenhuis; Shuyan Zhang; Arnau Vich Vila; Daan Kremer; Rianne M. Douwes; Adrian Post; Evelien E. Quint; Robert A. Pol; Bernadien H. Jansen; M. van Londen; Martin De Borst; Vincent E. de Meijer; Hans Blokzijl; Stefan Berger; Eleonora A. M. Festen; Alexandra Zhernakova; Jingyuan Fu; Hermie J.M. Harmsen; Stephan Bakker; Rinse K. Weersma

doi:10.1038/s41467-023-43431-8

Health-related quality of life is linked to the gut microbiome in kidney transplant recipients

TransplantLines Investigators, J. Casper Swarte, Tim J. Knobbe, Johannes R Björk, Ranko Gacesa, Lianne M. Nieuwenhuis, Shuyan Zhang, Arnau Vich Vila, Daan Kremer, Rianne M. Douwes, Adrian Post, Evelien E. Quint, Robert A. Pol, Bernadien H. Jansen, M. van Londen, Martin De Borst, Vincent E. de Meijer, Hans Blokzijl, Stefan Berger, Eleonora A. M. FestenAlexandra Zhernakova, Jingyuan Fu, Hermie J.M. Harmsen, Stephan Bakker, Rinse K. Weersma^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Kidney transplant recipients (KTR) have impaired health-related quality of life (HRQoL) and suffer from intestinal dysbiosis. Increasing evidence shows that gut health and HRQoL are tightly related in the general population. Here, we investigate the association between the gut microbiome and HRQoL in KTR, using metagenomic sequencing data from fecal samples collected from 507 KTR. Multiple bacterial species are associated with lower HRQoL, many of which have previously been associated with adverse health conditions. Gut microbiome distance to the general population is highest among KTR with an impaired physical HRQoL (R = -0.20, P = 2.3 × 10 -65) and mental HRQoL (R = -0.14, P = 1.3 × 10 -3). Physical and mental HRQoL explain a significant part of variance in the gut microbiome (R 2 = 0.58%, FDR = 5.43 × 10 -4 and R 2 = 0.37%, FDR = 1.38 × 10 -3, respectively). Additionally, multiple metabolic and neuroactive pathways (gut brain modules) are associated with lower HRQoL. While the observational design of our study does not allow us to analyze causality, we provide a comprehensive overview of the associations between the gut microbiome and HRQoL while controlling for confounders.

Original language	English
Article number	7968
Number of pages	11
Journal	Nature Communications
Volume	14
Issue number	1
Early online date	2-Dec-2023
DOIs	https://doi.org/10.1038/s41467-023-43431-8
Publication status	Published - 2-Dec-2023

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Health-related quality of life is linked to the gut microbiome in kidney transplant recipientsFinal publisher's version, 1.98 MBLicence: CC BY

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TransplantLines
Bakker, S. (Creator), Leuvenink, H. G. D. (Creator) & Porte, R. J. (Creator), University of Groningen, 2017
http://www.transplantlines.umcg.nl
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@article{021b1613339a43e9a4a8295df465d6eb,

title = "Health-related quality of life is linked to the gut microbiome in kidney transplant recipients",

abstract = "Kidney transplant recipients (KTR) have impaired health-related quality of life (HRQoL) and suffer from intestinal dysbiosis. Increasing evidence shows that gut health and HRQoL are tightly related in the general population. Here, we investigate the association between the gut microbiome and HRQoL in KTR, using metagenomic sequencing data from fecal samples collected from 507 KTR. Multiple bacterial species are associated with lower HRQoL, many of which have previously been associated with adverse health conditions. Gut microbiome distance to the general population is highest among KTR with an impaired physical HRQoL (R = -0.20, P = 2.3 × 10 -65) and mental HRQoL (R = -0.14, P = 1.3 × 10 -3). Physical and mental HRQoL explain a significant part of variance in the gut microbiome (R 2 = 0.58%, FDR = 5.43 × 10 -4 and R 2 = 0.37%, FDR = 1.38 × 10 -3, respectively). Additionally, multiple metabolic and neuroactive pathways (gut brain modules) are associated with lower HRQoL. While the observational design of our study does not allow us to analyze causality, we provide a comprehensive overview of the associations between the gut microbiome and HRQoL while controlling for confounders. ",

author = "{TransplantLines Investigators} and Swarte, {J. Casper} and Knobbe, {Tim J.} and Bj{\"o}rk, {Johannes R} and Ranko Gacesa and Nieuwenhuis, {Lianne M.} and Shuyan Zhang and Vila, {Arnau Vich} and Daan Kremer and Douwes, {Rianne M.} and Adrian Post and Quint, {Evelien E.} and Pol, {Robert A.} and Jansen, {Bernadien H.} and C. Annema and Bodewes, {F. A. J. A.} and Boer, {M. T. de} and K. Damman and A. Diepstra and G. Dijkstra and Doorenbos, {C. S. E.} and Eisenga, {M. F.} and Erasmus, {M. E.} and Gan, {C. T.} and Neto, {A. W. Gomes} and E. Hak and Hepkema, {B. G.} and Leuvenink, {H. G. D.} and Lexmond, {W. S.} and Nieuwenhuis-Moeke, {G. J.} and Niesters, {H. G. M.} and Pelt, {L. J. van} and Ranchor, {A. V.} and Sanders, {J. S. F.} and Siebelink, {M. J.} and Slart, {R. J. H. J. A.} and Touw, {D. J.} and Heuvel, {M. C. van den} and Leer-Buter, {C. van} and Londen, {M. van} and Verschuuren, {E. A. M.} and Vos, {M. J.} and Borst, {Martin De} and Meijer, {Vincent E. de} and Hans Blokzijl and Stefan Berger and Festen, {Eleonora A. M.} and Alexandra Zhernakova and Jingyuan Fu and Harmsen, {Hermie J.M.} and Stephan Bakker and Weersma, {Rinse K.}",

note = "{\textcopyright} 2023. The Author(s).",

year = "2023",

month = dec,

day = "2",

doi = "10.1038/s41467-023-43431-8",

language = "English",

volume = "14",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

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TransplantLines Investigators, Swarte, JC , Knobbe, TJ , Björk, JR , Gacesa, R , Nieuwenhuis, LM , Zhang, S , Vila, AV , Kremer, D, Douwes, RM, Post, A, Quint, EE, Pol, RA , Jansen, BH , Londen, MV , Borst, MD , Meijer, VED , Blokzijl, H , Berger, S , Festen, EAM , Zhernakova, A , Fu, J , Harmsen, HJM , Bakker, S & Weersma, RK 2023, 'Health-related quality of life is linked to the gut microbiome in kidney transplant recipients', Nature Communications, vol. 14, no. 1, 7968. https://doi.org/10.1038/s41467-023-43431-8

TY - JOUR

T1 - Health-related quality of life is linked to the gut microbiome in kidney transplant recipients

AU - TransplantLines Investigators

AU - Swarte, J. Casper

AU - Knobbe, Tim J.

AU - Björk, Johannes R

AU - Gacesa, Ranko

AU - Nieuwenhuis, Lianne M.

AU - Zhang, Shuyan

AU - Vila, Arnau Vich

AU - Kremer, Daan

AU - Douwes, Rianne M.

AU - Post, Adrian

AU - Quint, Evelien E.

AU - Pol, Robert A.

AU - Jansen, Bernadien H.

AU - Annema, C.

AU - Bodewes, F. A. J. A.

AU - Boer, M. T. de

AU - Damman, K.

AU - Diepstra, A.

AU - Dijkstra, G.

AU - Doorenbos, C. S. E.

AU - Eisenga, M. F.

AU - Erasmus, M. E.

AU - Gan, C. T.

AU - Neto, A. W. Gomes

AU - Hak, E.

AU - Hepkema, B. G.

AU - Leuvenink, H. G. D.

AU - Lexmond, W. S.

AU - Nieuwenhuis-Moeke, G. J.

AU - Niesters, H. G. M.

AU - Pelt, L. J. van

AU - Ranchor, A. V.

AU - Sanders, J. S. F.

AU - Siebelink, M. J.

AU - Slart, R. J. H. J. A.

AU - Touw, D. J.

AU - Heuvel, M. C. van den

AU - Leer-Buter, C. van

AU - Londen, M. van

AU - Verschuuren, E. A. M.

AU - Vos, M. J.

AU - Borst, Martin De

AU - Meijer, Vincent E. de

AU - Blokzijl, Hans

AU - Berger, Stefan

AU - Festen, Eleonora A. M.

AU - Zhernakova, Alexandra

AU - Fu, Jingyuan

AU - Harmsen, Hermie J.M.

AU - Bakker, Stephan

AU - Weersma, Rinse K.

PY - 2023/12/2

Y1 - 2023/12/2

N2 - Kidney transplant recipients (KTR) have impaired health-related quality of life (HRQoL) and suffer from intestinal dysbiosis. Increasing evidence shows that gut health and HRQoL are tightly related in the general population. Here, we investigate the association between the gut microbiome and HRQoL in KTR, using metagenomic sequencing data from fecal samples collected from 507 KTR. Multiple bacterial species are associated with lower HRQoL, many of which have previously been associated with adverse health conditions. Gut microbiome distance to the general population is highest among KTR with an impaired physical HRQoL (R = -0.20, P = 2.3 × 10 -65) and mental HRQoL (R = -0.14, P = 1.3 × 10 -3). Physical and mental HRQoL explain a significant part of variance in the gut microbiome (R 2 = 0.58%, FDR = 5.43 × 10 -4 and R 2 = 0.37%, FDR = 1.38 × 10 -3, respectively). Additionally, multiple metabolic and neuroactive pathways (gut brain modules) are associated with lower HRQoL. While the observational design of our study does not allow us to analyze causality, we provide a comprehensive overview of the associations between the gut microbiome and HRQoL while controlling for confounders.

AB - Kidney transplant recipients (KTR) have impaired health-related quality of life (HRQoL) and suffer from intestinal dysbiosis. Increasing evidence shows that gut health and HRQoL are tightly related in the general population. Here, we investigate the association between the gut microbiome and HRQoL in KTR, using metagenomic sequencing data from fecal samples collected from 507 KTR. Multiple bacterial species are associated with lower HRQoL, many of which have previously been associated with adverse health conditions. Gut microbiome distance to the general population is highest among KTR with an impaired physical HRQoL (R = -0.20, P = 2.3 × 10 -65) and mental HRQoL (R = -0.14, P = 1.3 × 10 -3). Physical and mental HRQoL explain a significant part of variance in the gut microbiome (R 2 = 0.58%, FDR = 5.43 × 10 -4 and R 2 = 0.37%, FDR = 1.38 × 10 -3, respectively). Additionally, multiple metabolic and neuroactive pathways (gut brain modules) are associated with lower HRQoL. While the observational design of our study does not allow us to analyze causality, we provide a comprehensive overview of the associations between the gut microbiome and HRQoL while controlling for confounders.

U2 - 10.1038/s41467-023-43431-8

DO - 10.1038/s41467-023-43431-8

M3 - Article

C2 - 38042820

SN - 2041-1723

VL - 14

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 7968

ER -

Health-related quality of life is linked to the gut microbiome in kidney transplant recipients

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