Healthy aging and disease: role for telomere biology?

Haidong Zhu*, Matthew Belcher, Pim van der Harst

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

109 Citations (Scopus)

Abstract

Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease, Type 2 diabetes, neurological diseases and cancer. Despite the remarkable progress made during the last two decades, our understanding of the biology of aging remains incomplete. Telomere biology has recently emerged as an important player in the aging and disease process.

Original languageEnglish
Pages (from-to)427-440
Number of pages14
JournalClinical Science
Volume120
Issue number9-10
DOIs
Publication statusPublished - May-2011

Keywords

  • aging
  • Alzheimer's disease
  • atherosclerosis
  • heart failure
  • longevity
  • Parkinson's disease
  • telomerase
  • telomere
  • CHRONIC HEART-FAILURE
  • REVERSE-TRANSCRIPTASE HTERT
  • GENOME-WIDE ASSOCIATION
  • REPEAT-CONTAINING RNA
  • ENDOTHELIAL PROGENITOR CELLS
  • BLOOD MONONUCLEAR-CELLS
  • SMOOTH-MUSCLE-CELLS
  • CARDIOVASCULAR-DISEASE
  • OXIDATIVE STRESS
  • HEMODIALYSIS-PATIENTS

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