Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

Christina C Spevak; Harold K Elias; Lavanya Kannan; Mohamed A E Ali; Gaëlle H Martin; Shanmugapriya Selvaraj; William S Eng; Amanda Ernlund; Vinagolu K Rajasekhar; Carolien M Woolthuis; Guangjie Zhao; Caryn J Ha; Robert J Schneider; Christopher Y Park

doi:10.1016/j.stem.2019.12.006

Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

Christina C Spevak, Harold K Elias, Lavanya Kannan, Mohamed A E Ali, Gaëlle H Martin, Shanmugapriya Selvaraj, William S Eng, Amanda Ernlund, Vinagolu K Rajasekhar, Carolien M Woolthuis, Guangjie Zhao, Caryn J Ha, Robert J Schneider, Christopher Y Park

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Abstract

The mechanisms that regulate protein synthesis in hematopoietic stem and progenitor cells (HSPCs) are poorly understood. Spevak, Elias, and colleagues provide a comprehensive characterization of the translatome in mouse HSPCs and show that mTOR- and CDK1-dependent mechanisms activate translation during distinct steps in hematopoietic development.

Original language	English
Pages (from-to)	755-765.e7
Number of pages	19
Journal	Cell stem cell
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/j.stem.2019.12.006
Publication status	Published - 7-May-2020

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Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent MechanismsFinal publisher's version, 3.3 MBLicence: Taverne

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Spevak, C. C., Elias, H. K., Kannan, L., Ali, M. A. E., Martin, G. H., Selvaraj, S., Eng, W. S., Ernlund, A., Rajasekhar, V. K., Woolthuis, C. M., Zhao, G., Ha, C. J., Schneider, R. J., & Park, C. Y. (2020). Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms. Cell stem cell, 26(5), 755-765.e7. https://doi.org/10.1016/j.stem.2019.12.006

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abstract = "The mechanisms that regulate protein synthesis in hematopoietic stem and progenitor cells (HSPCs) are poorly understood. Spevak, Elias, and colleagues provide a comprehensive characterization of the translatome in mouse HSPCs and show that mTOR- and CDK1-dependent mechanisms activate translation during distinct steps in hematopoietic development.",

author = "Spevak, {Christina C} and Elias, {Harold K} and Lavanya Kannan and Ali, {Mohamed A E} and Martin, {Ga{\"e}lle H} and Shanmugapriya Selvaraj and Eng, {William S} and Amanda Ernlund and Rajasekhar, {Vinagolu K} and Woolthuis, {Carolien M} and Guangjie Zhao and Ha, {Caryn J} and Schneider, {Robert J} and Park, {Christopher Y}",

year = "2020",

month = may,

day = "7",

doi = "10.1016/j.stem.2019.12.006",

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Spevak, CC, Elias, HK, Kannan, L, Ali, MAE, Martin, GH, Selvaraj, S, Eng, WS, Ernlund, A, Rajasekhar, VK, Woolthuis, CM, Zhao, G, Ha, CJ, Schneider, RJ & Park, CY 2020, 'Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms', Cell stem cell, vol. 26, no. 5, pp. 755-765.e7. https://doi.org/10.1016/j.stem.2019.12.006

TY - JOUR

T1 - Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

AU - Spevak, Christina C

AU - Elias, Harold K

AU - Kannan, Lavanya

AU - Ali, Mohamed A E

AU - Martin, Gaëlle H

AU - Selvaraj, Shanmugapriya

AU - Eng, William S

AU - Ernlund, Amanda

AU - Rajasekhar, Vinagolu K

AU - Woolthuis, Carolien M

AU - Zhao, Guangjie

AU - Ha, Caryn J

AU - Schneider, Robert J

AU - Park, Christopher Y

PY - 2020/5/7

Y1 - 2020/5/7

N2 - The mechanisms that regulate protein synthesis in hematopoietic stem and progenitor cells (HSPCs) are poorly understood. Spevak, Elias, and colleagues provide a comprehensive characterization of the translatome in mouse HSPCs and show that mTOR- and CDK1-dependent mechanisms activate translation during distinct steps in hematopoietic development.

AB - The mechanisms that regulate protein synthesis in hematopoietic stem and progenitor cells (HSPCs) are poorly understood. Spevak, Elias, and colleagues provide a comprehensive characterization of the translatome in mouse HSPCs and show that mTOR- and CDK1-dependent mechanisms activate translation during distinct steps in hematopoietic development.

U2 - 10.1016/j.stem.2019.12.006

DO - 10.1016/j.stem.2019.12.006

M3 - Article

C2 - 32386556

SN - 1934-5909

VL - 26

SP - 755-765.e7

JO - Cell stem cell

JF - Cell stem cell

IS - 5

ER -

Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

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