Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

Christina C Spevak; Harold K Elias; Lavanya Kannan; Mohamed A E Ali; Gaëlle H Martin; Shanmugapriya Selvaraj; William S Eng; Amanda Ernlund; Vinagolu K Rajasekhar; Carolien M Woolthuis; Guangjie Zhao; Caryn J Ha; Robert J Schneider; Christopher Y Park

doi:10.1016/j.stem.2019.12.006

Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

Christina C Spevak
, Harold K Elias
, Lavanya Kannan
, Mohamed A E Ali
, Gaëlle H Martin
, Shanmugapriya Selvaraj
, William S Eng
, Amanda Ernlund
, Vinagolu K Rajasekhar
, Carolien M Woolthuis
, Guangjie Zhao
, Caryn J Ha
, Robert J Schneider
, Christopher Y Park

Research output: Contribution to journal › Article › Academic › peer-review

32 Citations (Scopus)

134 Downloads (Pure)

Abstract

The mechanisms that regulate protein synthesis in hematopoietic stem and progenitor cells (HSPCs) are poorly understood. Spevak, Elias, and colleagues provide a comprehensive characterization of the translatome in mouse HSPCs and show that mTOR- and CDK1-dependent mechanisms activate translation during distinct steps in hematopoietic development.

Original language	English
Pages (from-to)	755-765.e7
Number of pages	19
Journal	Cell stem cell
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/j.stem.2019.12.006
Publication status	Published - 7-May-2020

Access to Document

10.1016/j.stem.2019.12.006

Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent MechanismsFinal publisher's version, 3.3 MBLicence: Taverne

Handle.net

Persistent link

Cite this

Spevak, C. C., Elias, H. K., Kannan, L., Ali, M. A. E., Martin, G. H., Selvaraj, S., Eng, W. S., Ernlund, A., Rajasekhar, V. K., Woolthuis, C. M., Zhao, G., Ha, C. J., Schneider, R. J., & Park, C. Y. (2020). Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms. Cell stem cell, 26(5), 755-765.e7. https://doi.org/10.1016/j.stem.2019.12.006

@article{0b1c681b60b845998b0c715bd793029f,

title = "Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms",

abstract = "The mechanisms that regulate protein synthesis in hematopoietic stem and progenitor cells (HSPCs) are poorly understood. Spevak, Elias, and colleagues provide a comprehensive characterization of the translatome in mouse HSPCs and show that mTOR- and CDK1-dependent mechanisms activate translation during distinct steps in hematopoietic development.",

author = "Spevak, \{Christina C\} and Elias, \{Harold K\} and Lavanya Kannan and Ali, \{Mohamed A E\} and Martin, \{Ga{\"e}lle H\} and Shanmugapriya Selvaraj and Eng, \{William S\} and Amanda Ernlund and Rajasekhar, \{Vinagolu K\} and Woolthuis, \{Carolien M\} and Guangjie Zhao and Ha, \{Caryn J\} and Schneider, \{Robert J\} and Park, \{Christopher Y\}",

year = "2020",

month = may,

day = "7",

doi = "10.1016/j.stem.2019.12.006",

language = "English",

volume = "26",

pages = "755--765.e7",

journal = "Cell stem cell",

issn = "1934-5909",

publisher = "Cell Press",

number = "5",

}

Spevak, CC, Elias, HK, Kannan, L, Ali, MAE, Martin, GH, Selvaraj, S, Eng, WS, Ernlund, A, Rajasekhar, VK, Woolthuis, CM, Zhao, G, Ha, CJ, Schneider, RJ & Park, CY 2020, 'Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms', Cell stem cell, vol. 26, no. 5, pp. 755-765.e7. https://doi.org/10.1016/j.stem.2019.12.006

TY - JOUR

T1 - Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

AU - Spevak, Christina C

AU - Elias, Harold K

AU - Kannan, Lavanya

AU - Ali, Mohamed A E

AU - Martin, Gaëlle H

AU - Selvaraj, Shanmugapriya

AU - Eng, William S

AU - Ernlund, Amanda

AU - Rajasekhar, Vinagolu K

AU - Woolthuis, Carolien M

AU - Zhao, Guangjie

AU - Ha, Caryn J

AU - Schneider, Robert J

AU - Park, Christopher Y

PY - 2020/5/7

Y1 - 2020/5/7

N2 - The mechanisms that regulate protein synthesis in hematopoietic stem and progenitor cells (HSPCs) are poorly understood. Spevak, Elias, and colleagues provide a comprehensive characterization of the translatome in mouse HSPCs and show that mTOR- and CDK1-dependent mechanisms activate translation during distinct steps in hematopoietic development.

AB - The mechanisms that regulate protein synthesis in hematopoietic stem and progenitor cells (HSPCs) are poorly understood. Spevak, Elias, and colleagues provide a comprehensive characterization of the translatome in mouse HSPCs and show that mTOR- and CDK1-dependent mechanisms activate translation during distinct steps in hematopoietic development.

U2 - 10.1016/j.stem.2019.12.006

DO - 10.1016/j.stem.2019.12.006

M3 - Article

C2 - 32386556

SN - 1934-5909

VL - 26

SP - 755-765.e7

JO - Cell stem cell

JF - Cell stem cell

IS - 5

ER -

Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

Abstract

Access to Document

Handle.net

Fingerprint

Cite this