Hemoglobin levels and 30-day mortality in patients after myocardial infarction

E Lipsic; ICC van der Horst; AA Voors; P van der Meer; MWN Nijsten; WH van Gilst; DJ van Veldhuisen; F Zijlstra

doi:10.1016/j.icard.2004.10.043

Hemoglobin levels and 30-day mortality in patients after myocardial infarction

E Lipsic, ICC van der Horst, AA Voors, P van der Meer, MWN Nijsten, WH van Gilst, DJ van Veldhuisen^*, F Zijlstra

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

71 Citations (Scopus)

Abstract

Background: Anemia is an independent risk factor for cardiovascular (CV) outcomes in patients with coronary artery disease and heart failure. However, the effect of hemoglobin levels on short-term CV mortality in patients with acute myocardial infarction (MI) remains unclear.

Methods: In a retrospective study we analyzed 1841 consecutive patients admitted with the diagnosis of acute MI. The primary end-point of the study was 30-day mortality. Patients were categorized according to the hemoglobin level on admission (10 g/dl or less, or greater than 10 g/dl).

Results: The overall 30-day mortality was 10.3%. The mortality was 21.6% in patients with hemoglobin levels on admission 10 g/dl (p <0.001). Multivariate logistic regression analysis showed, that lower hemoglobin concentration is an independent predictor of 30-day mortality, when adjusted for other risk factors (HR 1.76, CI 1.08-2.85; p = 0.02).

Conclusions: Lower levels of hemoglobin are associated with higher short-term mortality in patients with acute MI. Specific therapeutic strategies in anemic patients with MI should be further considered. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	289-292
Number of pages	4
Journal	International Journal of Cardiology
Volume	100
Issue number	2
DOIs	https://doi.org/10.1016/j.icard.2004.10.043
Publication status	Published - 20-Apr-2005

Keywords

myocardial infarction
hemoglobin
30-day mortality
CHRONIC HEART-FAILURE
CRITICALLY ILL PATIENTS
CARDIOVASCULAR-DISEASE
CORONARY STENOSIS
BLOOD-TRANSFUSION
ANEMIA
RISK
ERYTHROPOIETIN
HEMATOCRIT
TRIAL

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@article{3fe62c4d9fcc43f9a48010fba6c1b1ba,

title = "Hemoglobin levels and 30-day mortality in patients after myocardial infarction",

abstract = "Background: Anemia is an independent risk factor for cardiovascular (CV) outcomes in patients with coronary artery disease and heart failure. However, the effect of hemoglobin levels on short-term CV mortality in patients with acute myocardial infarction (MI) remains unclear.Methods: In a retrospective study we analyzed 1841 consecutive patients admitted with the diagnosis of acute MI. The primary end-point of the study was 30-day mortality. Patients were categorized according to the hemoglobin level on admission (10 g/dl or less, or greater than 10 g/dl).Results: The overall 30-day mortality was 10.3%. The mortality was 21.6% in patients with hemoglobin levels on admission 10 g/dl (p <0.001). Multivariate logistic regression analysis showed, that lower hemoglobin concentration is an independent predictor of 30-day mortality, when adjusted for other risk factors (HR 1.76, CI 1.08-2.85; p = 0.02).Conclusions: Lower levels of hemoglobin are associated with higher short-term mortality in patients with acute MI. Specific therapeutic strategies in anemic patients with MI should be further considered. (c) 2005 Elsevier Ireland Ltd. All rights reserved.",

keywords = "myocardial infarction, hemoglobin, 30-day mortality, CHRONIC HEART-FAILURE, CRITICALLY ILL PATIENTS, CARDIOVASCULAR-DISEASE, CORONARY STENOSIS, BLOOD-TRANSFUSION, ANEMIA, RISK, ERYTHROPOIETIN, HEMATOCRIT, TRIAL",

author = "E Lipsic and {van der Horst}, ICC and AA Voors and {van der Meer}, P and MWN Nijsten and {van Gilst}, WH and {van Veldhuisen}, DJ and F Zijlstra",

note = "J rticle",

year = "2005",

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doi = "10.1016/j.icard.2004.10.043",

language = "English",

volume = "100",

pages = "289--292",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "ELSEVIER IRELAND LTD",

number = "2",

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TY - JOUR

T1 - Hemoglobin levels and 30-day mortality in patients after myocardial infarction

AU - Lipsic, E

AU - van der Horst, ICC

AU - Voors, AA

AU - van der Meer, P

AU - Nijsten, MWN

AU - van Gilst, WH

AU - van Veldhuisen, DJ

AU - Zijlstra, F

N1 - J rticle

PY - 2005/4/20

Y1 - 2005/4/20

N2 - Background: Anemia is an independent risk factor for cardiovascular (CV) outcomes in patients with coronary artery disease and heart failure. However, the effect of hemoglobin levels on short-term CV mortality in patients with acute myocardial infarction (MI) remains unclear.Methods: In a retrospective study we analyzed 1841 consecutive patients admitted with the diagnosis of acute MI. The primary end-point of the study was 30-day mortality. Patients were categorized according to the hemoglobin level on admission (10 g/dl or less, or greater than 10 g/dl).Results: The overall 30-day mortality was 10.3%. The mortality was 21.6% in patients with hemoglobin levels on admission 10 g/dl (p <0.001). Multivariate logistic regression analysis showed, that lower hemoglobin concentration is an independent predictor of 30-day mortality, when adjusted for other risk factors (HR 1.76, CI 1.08-2.85; p = 0.02).Conclusions: Lower levels of hemoglobin are associated with higher short-term mortality in patients with acute MI. Specific therapeutic strategies in anemic patients with MI should be further considered. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

AB - Background: Anemia is an independent risk factor for cardiovascular (CV) outcomes in patients with coronary artery disease and heart failure. However, the effect of hemoglobin levels on short-term CV mortality in patients with acute myocardial infarction (MI) remains unclear.Methods: In a retrospective study we analyzed 1841 consecutive patients admitted with the diagnosis of acute MI. The primary end-point of the study was 30-day mortality. Patients were categorized according to the hemoglobin level on admission (10 g/dl or less, or greater than 10 g/dl).Results: The overall 30-day mortality was 10.3%. The mortality was 21.6% in patients with hemoglobin levels on admission 10 g/dl (p <0.001). Multivariate logistic regression analysis showed, that lower hemoglobin concentration is an independent predictor of 30-day mortality, when adjusted for other risk factors (HR 1.76, CI 1.08-2.85; p = 0.02).Conclusions: Lower levels of hemoglobin are associated with higher short-term mortality in patients with acute MI. Specific therapeutic strategies in anemic patients with MI should be further considered. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

KW - myocardial infarction

KW - hemoglobin

KW - 30-day mortality

KW - CHRONIC HEART-FAILURE

KW - CRITICALLY ILL PATIENTS

KW - CARDIOVASCULAR-DISEASE

KW - CORONARY STENOSIS

KW - BLOOD-TRANSFUSION

KW - ANEMIA

KW - RISK

KW - ERYTHROPOIETIN

KW - HEMATOCRIT

KW - TRIAL

U2 - 10.1016/j.icard.2004.10.043

DO - 10.1016/j.icard.2004.10.043

M3 - Article

SN - 0167-5273

VL - 100

SP - 289

EP - 292

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 2

ER -

Hemoglobin levels and 30-day mortality in patients after myocardial infarction

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