Hepatic First-Pass Effect of Thiazinamium Methylsulfate (N-Methylpromethazine Methylsulfate) in Dogs

JHG Jonkman; HGM Westenberg; E van der Kleyn

doi:10.1002/jps.2600700831

Hepatic First-Pass Effect of Thiazinamium Methylsulfate (N-Methylpromethazine Methylsulfate) in Dogs

JHG Jonkman^*, HGM Westenberg, E van der Kleyn

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Abstract

Plasma concentration-time curves are described for the intravenous infusion and portal vein infusion of the quaternary ammonium compound thiazinamium methylsulfate to dogs. Comparison of areas under the curve indicate that hepatic first-pass elimination occurred on the order of 25-50%.

Original language	English
Pages (from-to)	947-949
Number of pages	3
Journal	Journal of Pharmaceutical Sciences
Volume	70
Issue number	8
DOIs	https://doi.org/10.1002/jps.2600700831
Publication status	Published - 1981

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@article{0733632c804f4dcfb079faac76aa2f1c,

title = "Hepatic First-Pass Effect of Thiazinamium Methylsulfate (N-Methylpromethazine Methylsulfate) in Dogs",

abstract = "Plasma concentration-time curves are described for the intravenous infusion and portal vein infusion of the quaternary ammonium compound thiazinamium methylsulfate to dogs. Comparison of areas under the curve indicate that hepatic first-pass elimination occurred on the order of 25-50%.",

author = "JHG Jonkman and HGM Westenberg and {van der Kleyn}, E",

year = "1981",

doi = "10.1002/jps.2600700831",

language = "English",

volume = "70",

pages = "947--949",

journal = "Journal of Pharmaceutical Sciences",

issn = "0022-3549",

publisher = "ELSEVIER SCIENCE INC",

number = "8",

}

TY - JOUR

T1 - Hepatic First-Pass Effect of Thiazinamium Methylsulfate (N-Methylpromethazine Methylsulfate) in Dogs

AU - Jonkman, JHG

AU - Westenberg, HGM

AU - van der Kleyn, E

PY - 1981

Y1 - 1981

N2 - Plasma concentration-time curves are described for the intravenous infusion and portal vein infusion of the quaternary ammonium compound thiazinamium methylsulfate to dogs. Comparison of areas under the curve indicate that hepatic first-pass elimination occurred on the order of 25-50%.

AB - Plasma concentration-time curves are described for the intravenous infusion and portal vein infusion of the quaternary ammonium compound thiazinamium methylsulfate to dogs. Comparison of areas under the curve indicate that hepatic first-pass elimination occurred on the order of 25-50%.

U2 - 10.1002/jps.2600700831

DO - 10.1002/jps.2600700831

M3 - Comment/Letter to the editor

SN - 0022-3549

VL - 70

SP - 947

EP - 949

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

IS - 8

ER -

Hepatic First-Pass Effect of Thiazinamium Methylsulfate (N-Methylpromethazine Methylsulfate) in Dogs

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