Hepatic First-Pass Effect of Thiazinamium Methylsulfate (N-Methylpromethazine Methylsulfate) in Dogs

JHG Jonkman*, HGM Westenberg, E van der Kleyn

*Corresponding author for this work

    Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

    1 Citation (Scopus)


    Plasma concentration-time curves are described for the intravenous infusion and portal vein infusion of the quaternary ammonium compound thiazinamium methylsulfate to dogs. Comparison of areas under the curve indicate that hepatic first-pass elimination occurred on the order of 25-50%.
    Original languageEnglish
    Pages (from-to)947-949
    Number of pages3
    JournalJournal of Pharmaceutical Sciences
    Issue number8
    Publication statusPublished - 1981

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