Hermann Senator and albuminuria-025EFforgotten pioneering work in the 19th century

Ron T. Gansevoort, Eberhard Ritz*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Testing urinary albumin concentration by immune detection methods has recently turned out to be a highly rewarding procedure, as low level albumin excretion has turned out to be a powerful predictor of cardiovascular and renal risk in diabetic and nondiabetic patients. In the following we discuss a text dating back to the 19th century in order to make today's nephrologists aware of the remarkable and prescient, but meanwhile completely forgotten investigations on urinary albumin excretion in individuals without primary kidney disease. The treatise of Hermann Senator convincingly disproved the then held dogma that albuminuria was always a sign of primary renal disease. These observations are all the more remarkable since he was forced to use relatively simple and not absolutely specific methods. He further provided an explanation of the renal handling of albumin which to a large extent is still valid today.

Original languageEnglish
Pages (from-to)1057-1062
Number of pages6
JournalNephrology Dialysis Transplantation
Volume24
Issue number3
DOIs
Publication statusPublished - Mar-2009

Keywords

  • albuminuria without kidney disease
  • albuminuria
  • glomerular filtration
  • history
  • microalbuminuria
  • CHRONIC KIDNEY-DISEASE
  • URINARY ALBUMIN
  • DIABETES-MELLITUS
  • MICROALBUMINURIA
  • MORTALITY
  • PROTEINURIA
  • POPULATION
  • PREVALENCE
  • RISK

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