Het cytochroom P450 enzymsysteem: Wat is de relevantie voor de praktijk? Deel II, interacties

Translated title of the contribution: The cytochrome p450 enzyme system: What is its relevance for the practice? Part II - The interactions

D.J. Touw, W.M.A. Verhoeven, J.B.G.M. Noten

Research output: Contribution to journalBook/Film/Article reviewProfessional

5 Citations (Scopus)

Abstract

In man a great interindividual variability exists in the oxidative capacity to metabolize drugs. A major factor contributing to this phenomenon is the genetically determined hydroxylation-capacity of the cytochrome P450 enzyme system. The cytochrome P450 system comprises of several isozymes. For several isozymes (CYP2D6, CYP2C) a genetically based hydroxylation capacity has been demonstrated. A frequency distribution of the clearance shows a bimodal distribution with poor and extensive metabolizers. Applying standard dosing schemes of the drugs that are predominantly metabolised by these isozymes, a considerable number of patients will be intoxicated because of poor metabolism. In general, cytochrome P450 capacity is limited and substrate-affinity is high. Henceforth cytochrome P450 isozymes are likely targets for pharmacokinetic interactions.
Translated title of the contributionThe cytochrome p450 enzyme system: What is its relevance for the practice? Part II - The interactions
Original languageDutch
Pages (from-to)58-62
Number of pages5
JournalActa Neuropsychiatrica
Volume10
Issue number3
Publication statusPublished - 16-Oct-1998

Keywords

  • Cytochrome P450
  • Drug metabolism
  • Genetic polymorfism
  • Hydroxylation capacity
  • Liver enzymes
  • Metabolism
  • Substrate affinity
  • alprazolam
  • antibiotic agent
  • azithromycin
  • carbamazepine
  • chlorpromazine
  • cimetidine
  • ciprofloxacin
  • clarithromycin
  • cyclosporin
  • cyclosporin A
  • cytochrome P450
  • cytochrome P450 isoenzyme
  • difantoine
  • fluoxetine
  • haloperidol
  • indinavir
  • liver enzyme
  • methadone
  • moclobemide
  • phenobarbital
  • phenytoin
  • propranolol
  • quinidine
  • quinidine polygalacturonate
  • rifampicin
  • roxithromycin
  • saquinavir
  • sertindole
  • sertraline
  • theophylline
  • thioridazine
  • triazolam
  • unclassified drug
  • unindexed drug
  • depression
  • drug hydroxylation
  • drug metabolism
  • drug oxidation
  • enzyme analysis
  • epilepsy
  • genetic polymorphism
  • heart arrhythmia
  • human
  • psychosis
  • review

Fingerprint

Dive into the research topics of 'The cytochrome p450 enzyme system: What is its relevance for the practice? Part II - The interactions: Wat is de relevantie voor de praktijk? Deel II, interacties'. Together they form a unique fingerprint.

Cite this